阿尔茨海默病中皮质路易体、视力不佳与幻觉之间关系的前瞻性研究。
Prospective study of relations between cortical Lewy bodies, poor eyesight, and hallucinations in Alzheimer's disease.
作者信息
McShane R, Gedling K, Reading M, McDonald B, Esiri M M, Hope T
机构信息
Department of Psychiatry of Old Age, Radcliffe Infirmary, Oxford, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1995 Aug;59(2):185-8. doi: 10.1136/jnnp.59.2.185.
Abstract
The presence of hallucinations is included in some, but not all, of the sets of clinical diagnostic criteria that have been proposed for dementia associated with cortical Lewy bodies. These criteria were developed from retrospective casenote analyses. This prospective, longitudinal study suggests that, in patients with Alzheimer's disease, cortical Lewy bodies are associated with more persistent and severe hallucinations, independently of any association with severity of cognitive decline. Poor eyesight contributes to the severity but not the persistence of the hallucinations.
摘要
幻觉的存在被纳入了一些（但并非全部）已提出的与皮质路易体痴呆相关的临床诊断标准组中。这些标准是通过回顾性病例记录分析制定的。这项前瞻性纵向研究表明，在阿尔茨海默病患者中，皮质路易体与更持续、更严重的幻觉相关，与认知衰退的严重程度无关。视力不佳会加重幻觉的严重程度，但不会导致幻觉持续存在。
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本文引用的文献
1
The Lewy-body variant of Alzheimer's disease. Clinical and pathological findings.阿尔茨海默病的路易体变异型。临床及病理发现。
Br J Psychiatry. 1993 Mar;162:385-92. doi: 10.1192/bjp.162.3.385.
2
Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists.阿尔茨海默病的诊断：执业病理学家入门指南
Arch Pathol Lab Med. 1993 Feb;117(2):132-44.
3
Alzheimer's disease and Lewy body disease: a comparative clinicopathological study.阿尔茨海默病与路易体病：一项比较性临床病理研究。
Ann Neurol. 1994 Jan;35(1):81-8. doi: 10.1002/ana.410350113.
4
The clinical diagnosis and misdiagnosis of senile dementia of Lewy body type (SDLT).路易体痴呆型老年痴呆症（SDLT）的临床诊断与误诊
Br J Psychiatry. 1994 Sep;165(3):324-32. doi: 10.1192/bjp.165.3.324.
5
Immunoreactivity profile of hippocampal CA2/3 neurites in diffuse Lewy body disease.弥漫性路易体病中海马CA2/3神经突的免疫反应性特征
Acta Neuropathol. 1994;87(3):269-76. doi: 10.1007/BF00296742.
6
The Charles Bonnet syndrome: a large prospective study in The Netherlands. A study of the prevalence of the Charles Bonnet syndrome and associated factors in 500 patients attending the University Department of Ophthalmology at Nijmegen.查尔斯·博内综合征：荷兰的一项大型前瞻性研究。一项针对奈梅亨大学眼科系500名患者的查尔斯·博内综合征患病率及相关因素的研究。
Br J Psychiatry. 1995 Feb;166(2):254-7. doi: 10.1192/bjp.166.2.254.
7
The psychiatric symptoms of Alzheimer's disease.阿尔茨海默病的精神症状。
J Am Geriatr Soc. 1988 Jan;36(1):7-12. doi: 10.1111/j.1532-5415.1988.tb03427.x.
8
Overview of depression and psychosis in Alzheimer's disease.阿尔茨海默病中的抑郁与精神病概述
Am J Psychiatry. 1989 May;146(5):577-87. doi: 10.1176/ajp.146.5.577.
9
Diffuse Lewy body disease: correlative neuropathology using anti-ubiquitin immunocytochemistry.弥漫性路易体病：运用抗泛素免疫细胞化学的相关神经病理学研究
J Neurol Neurosurg Psychiatry. 1989 Nov;52(11):1236-47. doi: 10.1136/jnnp.52.11.1236.
10
Diffuse Lewy body disease in Japan.日本的弥漫性路易体病。
J Neurol. 1990 Jun;237(3):197-204. doi: 10.1007/BF00314594.
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