Lennox G G, Lowe J S
University of Nottingham, UK.
Baillieres Clin Neurol. 1997 Apr;6(1):147-66.
Dementia with Lewy bodies (DLB) is the recommended term for a common cause of dementia characterized by the histological presence of distinctive inclusions within neurons, Lewy bodies (McKeith et al, 1996). Following increasing pathological recognition, core clinical diagnostic features have been identified to allow diagnosis in life. Insights into the biology of this type of neurodegeneration suggest that the regional patterns of involvement might allow therapeutic intervention. Although Lewy bodies had long been recognized in the substantia nigra and other subcortical nuclei in patients with Parkinson's disease (PD), it was only in the 1970s that a significant number of reports began to be published from Japan describing patients with dementia and parkinsonism associated with the presence of Lewy bodies in cortical neurons (reviewed by Kosaka, 1990). Since these reports, different workers have used a variety of terms to describe this disease process, including diffuse Lewy body disease (Yoshimura, 1983), Lewy body dementia (Gibb et al, 1987), senile dementia of Lewy body type (Perry et al, 1990a) and the Lewy body variant of Alzheimer's disease (Hansen et al, 1990).
路易体痴呆（DLB）是一种常见的痴呆病因的推荐术语，其特征是神经元内存在独特的包涵体——路易小体（McKeith等人，1996年）。随着病理认识的不断增加，已确定了核心临床诊断特征以便在生前进行诊断。对这种神经退行性变生物学的深入了解表明，受累的区域模式可能允许进行治疗干预。尽管在帕金森病（PD）患者的黑质和其他皮质下核团中早就发现了路易小体，但直到20世纪70年代，日本才开始发表大量报告，描述患有痴呆和帕金森综合征且皮质神经元中存在路易小体的患者（Kosaka综述，1990年）。自这些报告以来，不同的研究者使用了各种术语来描述这一疾病过程，包括弥漫性路易体病（Yoshimura，1983年）、路易体痴呆（Gibb等人，1987年）、路易体型老年性痴呆（Perry等人，1990a）以及阿尔茨海默病的路易体变异型（Hansen等人，1990年）。
