Bowsher D, Miles J B, Haggett C E, Eldridge P R
Pain Research Institute, Walton Hospital, Liverpool, England.
J Neurosurg. 1997 Feb;86(2):190-2. doi: 10.3171/jns.1997.86.2.0190.
The authors investigated 28 patients with "idiopathic" trigeminal neuralgia who had undergone no previous invasive procedures; together these patients had a total of 50 affected trigeminal divisions. Quantitative sensory perception thresholds were measured before operation. Preoperative measurements in the affected divisions indicated raised thresholds for touch (von Frey filaments) and temperature, but not for pinprick or heat pain, in agreement with the findings of Nurmikko. Only the tactile threshold was also significantly affected in the unaffected divisions on the affected side. The authors discuss their findings in relation to the pathophysiology of trigeminal neuralgia, concluding that the origin of the condition is almost certainly central to the gasserian ganglion.
作者对28例未曾接受过侵入性治疗的“特发性”三叉神经痛患者进行了研究；这些患者共有50个三叉神经分支受累。术前测量了定量感觉阈值。患侧分支的术前测量结果显示，触觉（用von Frey细丝）和温度阈值升高，但针刺或热痛阈值未升高，这与Nurmikko的研究结果一致。仅患侧未受累分支的触觉阈值也受到显著影响。作者结合三叉神经痛的病理生理学对他们的研究结果进行了讨论，得出结论认为该病的起源几乎肯定位于半月神经节中枢。
