Miles J B, Eldridge P R, Haggett C E, Bowsher D
Walton Centre for Neurology and Neurosurgery, Walton Hospital, Liverpool, England.
J Neurosurg. 1997 Feb;86(2):193-6. doi: 10.3171/jns.1997.86.2.0193.
Nineteen patients with "idiopathic" trigeminal neuralgia, who had not undergone any previous interventional procedures, possessed a vessel or vessels compressing the preganglionic nerve root that was demonstrated by magnetic resonance tomographic angiography. Pain was relieved immediately in all of these patients after they underwent microvascular decompression without observed nerve damage. Although preoperative measurement of sensory perception thresholds showed elevations in the thresholds for touch (von Frey filaments) and warmth and coolness sensations, these thresholds normalized during the postoperative period. An apparent deficit in the pinprick (sharpness) sensation appeared postoperatively, but the deficit gradually regressed and completely disappeared by 1 year after surgery; this phenomenon may have been a statistical anomaly. The patients' pain disappeared immediately postoperatively and remained absent throughout the follow-up period. The authors conclude that damage to the nerve or nerve root is not essential for the relief of trigeminal neuralgia.
19例“特发性”三叉神经痛患者，此前未接受过任何介入治疗，磁共振断层血管造影显示有血管压迫节前神经根。所有这些患者在接受微血管减压术后疼痛立即缓解，且未观察到神经损伤。尽管术前感觉阈测量显示触觉（von Frey细丝）、温觉和冷觉阈值升高，但这些阈值在术后恢复正常。术后出现了针刺（锐度）感觉明显缺失的情况，但这种缺失逐渐消退，术后1年完全消失；这种现象可能是统计学上的异常。患者术后疼痛立即消失，随访期间一直未再出现。作者得出结论，神经或神经根损伤并非缓解三叉神经痛所必需。
