Benelli A, Arletti R, Poggioli R, Cavazzuti E, Mameli M, Bertolini A
Department of Biomedical Sciences, University of Modena, Italy.
Life Sci. 1997;60(4-5):263-7. doi: 10.1016/s0024-3205(96)00626-1.
In the adult sexually experienced male rat, the intracerebroventricular (i.c.v.) injection of pinacidil, a KATP channel opener, at the dose of 100-150-300 micrograms/rat worsened the copulatory performance in the presence of a receptive female, whereas the administration of glibenclamide, a KATP channel blocker, at the dose of 0.5 and 3 mg/kg intraperitoneally (i.p.) had an improving effect. These data indicate that KATP channels in target neurons may play an important role in the physiology of male sexual behavior.
在成年有性经验的雄性大鼠中，脑室内（i.c.v.）注射100 - 150 - 300微克/大鼠剂量的吡那地尔（一种KATP通道开放剂）会在有发情雌性大鼠存在的情况下使交配行为恶化，而腹腔内（i.p.）注射0.5和3毫克/千克剂量的格列本脲（一种KATP通道阻滞剂）则具有改善作用。这些数据表明，靶神经元中的KATP通道可能在雄性性行为的生理过程中发挥重要作用。
