乙醇消除药代动力学——乙醛脱氢酶2（ALDH2）和细胞色素P450 2E1（CYP2E1）基因多态性对乙醇代谢的影响

[The ethanol elimination pharmacokinetics--the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism].

作者信息

Iwahashi K, Ameno K, Kinoshita H, Nakamura K, Miyatake R, Suwaki H, Ijiri I, Ishikawa Y, Ichikawa Y, Mendori T, Orino K

机构信息

Department of Neuropsychiatry, Faculty of Medicine, Kagawa Medical University, Japan.

出版信息

Nihon Arukoru Yakubutsu Igakkai Zasshi. 1996 Dec;31(6):517-24.

PMID:9011144

Abstract

The effects of the genotypes of CYP2E1, ALDH2, ADH upon the blood ethanol and acetaldehyde levels were investigated. The predicting 95% confidence bounds determined on regression analysis of the data suggested that after venous injection of ethanol, the blood ethanol and acetaldehyde concentrations in a volunteer normal homozygous for ALDH2 (ALDH21/1) were significantly lower than that heterozygous (ALDH21/2). And the blood ethanol and acetaldehyde concentrations in a volunteer with C2 allele (C1/C2) were significantly lower than that in (C1/1). However, there were no significant differences in the blood ethanol and acetaldehyde concentrations between volunteers with ADH21/1 and ALDH21/2. It is possible that the ALDH2*1 and C2 alleles may correspond to the lower blood ethanol and acetaldehyde concentrations after intravenous administrations of 0.2 g /kg of ethanol.

摘要

研究了细胞色素P450 2E1（CYP2E1）、乙醛脱氢酶2（ALDH2）、乙醇脱氢酶（ADH）的基因型对血液中乙醇和乙醛水平的影响。对数据进行回归分析确定的预测95%置信区间表明，静脉注射乙醇后，ALDH2基因正常纯合子（ALDH21/1）志愿者的血液乙醇和乙醛浓度显著低于杂合子（ALDH21/2）。携带C2等位基因（C1/C2）的志愿者的血液乙醇和乙醛浓度显著低于（C1/1）的志愿者。然而，ADH21/1和ALDH21/2的志愿者之间血液乙醇和乙醛浓度没有显著差异。静脉注射0.2 g/kg乙醇后，ALDH2*1和C2等位基因可能对应较低的血液乙醇和乙醛浓度。