Csendes A, Smok G, Coronel M, Avendaño R, Zenteno G, Cordova H
Gastrointestinal Unit, Department of Surgery University Hospital, Santiago, Chile.
Dig Dis Sci. 1996 Dec;41(12):2366-8. doi: 10.1007/BF02100129.
There are many recent studies that clearly suggest that Helicobacter pylori (HP) is an etiological agent for duodenal ulcer disease (1-3). Randomized trials have shown that duodenal ulcers treated by omeprazole or H2 blockers heal faster if HP is eradicated concurrently (4-6). Besides, several studies have demonstrated that eradication of HP significantly reduces duodenal ulcer relapses (7-9). Patients followed up to 7 years after eradication of HP demonstrated that 92% remained HP negative, with only 3% recurrence (10). Highly selective vagotomy has been the treatment of choice for duodenal ulcer patients who are candidates for surgical therapy (11, 12). The late results have shown an approximately 10% recurrence rate 8 to 10 years after surgery (13, 14). We hypothesized that in these asymptomatic cases after HSV, HP probably will exist in a minor proportion of cases, similar to what happens after successful medical antiulcer therapy. Therefore the purpose of the present study was to determine the HP status at the antrum in a group of nonoperated duodenal ulcer patients compared to a group submitted to highly selective vagotomy many years prior to the actual study.
最近有许多研究明确表明，幽门螺杆菌（HP）是十二指肠溃疡病的病原体（1-3）。随机试验表明，如果同时根除HP，用奥美拉唑或H2阻滞剂治疗的十二指肠溃疡愈合更快（4-6）。此外，多项研究表明，根除HP可显著降低十二指肠溃疡的复发率（7-9）。对根除HP后长达7年的患者进行随访发现，92%的患者HP仍为阴性，复发率仅为3%（10）。对于适合手术治疗的十二指肠溃疡患者，高选择性迷走神经切断术一直是首选治疗方法（11, 12）。后期结果显示，手术后8至10年的复发率约为10%（13, 14）。我们推测，在这些高选择性迷走神经切断术后的无症状病例中，HP可能仅存在于一小部分病例中，这与成功的抗溃疡药物治疗后的情况类似。因此，本研究的目的是确定一组未经手术的十二指肠溃疡患者胃窦部的HP状况，并与在实际研究多年前接受过高选择性迷走神经切断术的一组患者进行比较。
