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1
Eradication of Helicobacter pylori: therapies and clinical implications.幽门螺杆菌的根除：治疗方法及临床意义
Postgrad Med J. 1992 Jul;68(801):549-57. doi: 10.1136/pgmj.68.801.549.
2
Eradication of Helicobacter pylori.幽门螺杆菌的根除
Eur J Gastroenterol Hepatol. 1994 Dec;6 Suppl 1:S113-9.
3
Indications for treatment of Helicobacter pylori infection: a systematic overview.幽门螺杆菌感染的治疗指征：系统综述。
CMAJ. 1994 Jan 15;150(2):189-98.
4
Hormonal, secretory and morphological alterations in gastric mucosa in the course of Helicobacter pylori eradication in patients with duodenal ulcer and non-ulcer dyspepsia.十二指肠溃疡和非溃疡性消化不良患者根除幽门螺杆菌过程中胃黏膜的激素、分泌及形态学改变
J Physiol Pharmacol. 1997 Jun;48 Suppl 3:1-56.
5
Outcomes research in Helicobacter pylori infection.幽门螺杆菌感染的结局研究。
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Helicobacter pylori and dyspepsia: physicians' attitudes, clinical practice, and prescribing habits.幽门螺杆菌与消化不良：医生的态度、临床实践及处方习惯
Aliment Pharmacol Ther. 2002 Mar;16(3):487-96. doi: 10.1046/j.1365-2036.2002.01183.x.
7
The case for treatment of dyspeptic patients infected with H. pylori.治疗幽门螺杆菌感染的消化不良患者的理由。
Eur J Surg Suppl. 1998(582):6-10. doi: 10.1080/11024159850191373.
8
Are twelve days of omeprazole, amoxicillin and clarithromycin better than six days for treating H. pylori infection in peptic ulcer and in non-ulcer dyspepsia?对于治疗消化性溃疡和非溃疡性消化不良中的幽门螺杆菌感染，奥美拉唑、阿莫西林和克拉霉素联合使用12天是否比6天更有效？
Hepatogastroenterology. 2001 Sep-Oct;48(41):1383-8.
9
Cost-benefit analysis of testing for Helicobacter pylori in dyspeptic subjects.消化不良患者幽门螺杆菌检测的成本效益分析
Am J Gastroenterol. 1996 Sep;91(9):1773-7.
10
Treatment of Helicobacter pylori infections.幽门螺杆菌感染的治疗。
QJM. 1995 Jun;88(6):369-89.

引用本文的文献

1
Metronidazole resistance reduces efficacy of triple therapy and leads to secondary clarithromycin resistance.甲硝唑耐药会降低三联疗法的疗效，并导致继发性克拉霉素耐药。
Dig Dis Sci. 1997 Oct;42(10):2111-5. doi: 10.1023/a:1018882804607.
2
The presence of Helicobacter pylori in nonoperated duodenal ulcer patients compared to patients late after highly selective vagotomy.未接受手术的十二指肠溃疡患者与高选择性迷走神经切断术后晚期患者相比幽门螺杆菌的存在情况。
Dig Dis Sci. 1996 Dec;41(12):2366-8. doi: 10.1007/BF02100129.
3
Eradication of Helicobacter pylori and long-term outcome of functional dyspepsia. A clinical endoscopic study.幽门螺杆菌根除与功能性消化不良的长期结局：一项临床内镜研究
Dig Dis Sci. 1996 Aug;41(8):1589-94. doi: 10.1007/BF02087905.
4
Helicobacter pylori and gastro-oesophageal reflux disease--a prospective study.幽门螺杆菌与胃食管反流病——一项前瞻性研究。
Ir J Med Sci. 1994 Aug;163(8):369-73. doi: 10.1007/BF02942830.
5
Helicobacter pylori infection increases following cholecystectomy.胆囊切除术后幽门螺杆菌感染增加。
Ir J Med Sci. 1995 Jan;164(1):52-5. doi: 10.1007/BF02968117.
6
Helicobacter pylori: the place of the new macrolides in the eradication of the bacteria in peptic ulcer disease.幽门螺杆菌：新型大环内酯类药物在消化性溃疡疾病中根除该细菌的地位
Infection. 1995;23 Suppl 1:S44-52. doi: 10.1007/BF02464960.
7
Effect of Helicobacter pylori eradication on peptic ulcer healing.幽门螺杆菌根除对消化性溃疡愈合的影响。
Postgrad Med J. 1995 Feb;71(832):90-3. doi: 10.1136/pgmj.71.832.90.
8
Role of Helicobacter pylori in gastrointestinal disease: implications for primary care of a revolution in management of dyspepsia.幽门螺杆菌在胃肠道疾病中的作用：对消化不良管理革命中初级保健的启示。
Br J Gen Pract. 1995 Sep;45(398):489-94.

本文引用的文献

1
Role of intestinal metaplasia in the histogenesis of gastric carcinoma.肠化生在胃癌组织发生中的作用。
J Clin Pathol. 1980 Sep;33(9):801-10. doi: 10.1136/jcp.33.9.801.
2
Quantitative estimation of endogenous nitrosation in humans by monitoring N-nitrosoproline excreted in the urine.通过监测尿液中排泄的N-亚硝基脯氨酸对人体内源性亚硝化作用进行定量评估。
Cancer Res. 1981 Sep;41(9 Pt 1):3658-62.
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Duodeno-gastric reflux in normal and dyspeptic subjects.正常人和消化不良患者的十二指肠-胃反流
Clin Radiol. 1982 Jul;33(4):461-6. doi: 10.1016/s0009-9260(82)80320-6.
4
Location of N-methyl-N'-nitro-N-nitrosoguanidine-induced gastrointestinal tumors correlates with thiol distribution.N-甲基-N'-硝基-N-亚硝基胍诱导的胃肠道肿瘤的位置与硫醇分布相关。
Carcinogenesis. 1983;4(7):879-83. doi: 10.1093/carcin/4.7.879.
5
Does treatment with cimetidine extended beyond initial healing of duodenal ulcer reduce the subsequent relapse rate?西咪替丁治疗十二指肠溃疡，在溃疡初步愈合后继续用药，能否降低后续复发率？
Br Med J (Clin Res Ed). 1982 Feb 27;284(6316):621-3. doi: 10.1136/bmj.284.6316.621.
6
Correlation between O6-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-N'-nitro-N-nitrosoguanidine.O6-甲基鸟嘌呤-DNA甲基转移酶活性与人细胞对N-甲基-N'-硝基-N-亚硝基胍细胞毒性和诱变作用的抗性之间的相关性。
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The geography of cancer of the stomach.胃癌的地理分布
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8
Epidemiology of peptic ulcer disease.消化性溃疡疾病的流行病学
Clin Gastroenterol. 1984 May;13(2):289-307.
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Health and economic aspects of peptic ulcer disease.消化性溃疡疾病的健康与经济方面
Am J Med. 1984 Nov 19;77(5B):8-14.
10
Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.胃炎和消化性溃疡患者胃内不明弯曲杆菌。
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幽门螺杆菌的根除：治疗方法及临床意义

Eradication of Helicobacter pylori: therapies and clinical implications.

作者信息

O'Connor H J

机构信息

General Hospital, Tullamore, County Offaly, Eire.

出版信息

Postgrad Med J. 1992 Jul;68(801):549-57. doi: 10.1136/pgmj.68.801.549.

DOI:10.1136/pgmj.68.801.549
PMID:1437952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2399381/
Abstract

This review presents a critical evaluation of the role of Helicobacter pylori eradication in the management of peptic ulcer disease and non-ulcer dyspepsia. On current evidence, H. pylori eradication therapy seems likely to emerge as the most rational and cost-effective treatment for duodenal ulcer. The role of H. pylori eradication in the treatment of gastric ulcer and non-ulcer dyspepsia is unclear and requires further study. The emerging problem of antibiotic resistance in H. pylori is of major clinical importance and a prime cause of treatment failure. There is increasing evidence of a link between H. pylori and gastric cancer but it is premature to recommend large-scale eradication of H. pylori as a valid strategy for the primary prevention of gastric cancer. The search continues for the ideal H. pylori eradication regimen.

摘要

本综述对根除幽门螺杆菌在消化性溃疡疾病和非溃疡性消化不良管理中的作用进行了批判性评估。根据目前的证据，根除幽门螺杆菌治疗似乎有可能成为十二指肠溃疡最合理且最具成本效益的治疗方法。根除幽门螺杆菌在胃溃疡和非溃疡性消化不良治疗中的作用尚不清楚，需要进一步研究。幽门螺杆菌抗生素耐药性这一新兴问题具有重大临床意义，是治疗失败的主要原因。越来越多的证据表明幽门螺杆菌与胃癌之间存在联系，但将大规模根除幽门螺杆菌作为预防胃癌的有效策略推荐还为时过早。寻找理想的幽门螺杆菌根除方案的工作仍在继续。