Hetzel J, Herb S, Hetzel M, Rusteberg T, Kleiser G, Weber J, Kochs M, Hombach V
Abteilung Innere Medizin II, Universitätsklinik Ulm, Deutschland.
Wien Med Wochenschr. 1996;146(13-14):354-6.
13 patients with obstructive sleep apnea syndrome treated with CPAP-therapy and complicating affections of the nasal and pharyngeal mucosa were enrolled in a randomized cross-over study comparing therapy with a heated humidifier (HC 100, company Fisher & Paykel) and treatment with a heat and moisture exchanger (Typ I, company Dahlhausen). We assessed the bacterial and fungal colonisation of the nasal masks of all patients. Samples of mask rinses were taken after the two treatment periods (2 weeks each) and the period without humidification in between. All microbes were found to have pathological potency. There was no significant difference in the total concentration of the microbes in the different treatment modalities. In a few cases however, gram negative bacteria were detected on the masks during humidification with a heated humidifier, but not with heat and moisture exchangers. Legionella spec. were not detectable in any of the samples. Candida albicans was the only fungus detectable. No patient had any infection of the upper or lower respiratory system associated with humidification therapy.
13名接受持续气道正压通气（CPAP）治疗且伴有鼻和咽黏膜并发症的阻塞性睡眠呼吸暂停综合征患者被纳入一项随机交叉研究，该研究比较了使用加热加湿器（HC 100，费雪派克公司）治疗和使用热湿交换器（I型，达尔豪森公司）治疗的效果。我们评估了所有患者鼻罩上的细菌和真菌定植情况。在两个治疗期（各2周）以及其间不进行加湿的时期后，采集了面罩冲洗液样本。所有微生物均具有致病力。不同治疗方式下微生物的总浓度没有显著差异。然而，在少数情况下，使用加热加湿器加湿时在面罩上检测到革兰氏阴性菌，而使用热湿交换器时未检测到。未在任何样本中检测到嗜肺军团菌属。白色念珠菌是唯一可检测到的真菌。没有患者因加湿治疗出现上呼吸道或下呼吸道感染。
