Wilhelm B, Wilhelm H, Streicher P, Lüdtke H, Adler M
Abteilung für Pathophysiologie des Sehens und Neuroophthalmologie, Universitäts-Augenklinik Tübingen, Deutschland.
Wien Med Wochenschr. 1996;146(13-14):387-9.
Infrared video pupillography (IVP) allows continuous recording of spontaneous pupillary oscillations in darkness which change characteristically with fatigue. Pupil size in darkness is age-related, has its maximum in the second decade and subsequently decreases during life time. Normally, the pupil oscillates in darkness with a frequency of about 1 Hz and amplitudes of less than 0.3 mm. Excessive daytime sleepiness causes instability of this pupillary behaviour which is constant in alert normals, and so called fatigue waves appear with an amplitude reaching several millimeters. The frequency profile is dominated by slow frequencies below 0.5 Hz, while average pupil size decreases continuously with time. As IVP is an objective and time-saving method it could become an important supplement to test procedures used in sleep medicine and sleep research to measure daytime sleepiness.
红外视频瞳孔描记术（IVP）可在黑暗中连续记录自发瞳孔振荡，其特征会随疲劳而改变。黑暗中的瞳孔大小与年龄有关，在二十多岁时最大，随后在一生中逐渐减小。正常情况下，瞳孔在黑暗中以约1赫兹的频率振荡，振幅小于0.3毫米。白天过度嗜睡会导致这种在警觉正常人中恒定的瞳孔行为不稳定，出现所谓的疲劳波，振幅可达数毫米。频率分布以低于0.5赫兹的低频为主，而平均瞳孔大小随时间持续减小。由于IVP是一种客观且省时的方法，它可能成为睡眠医学和睡眠研究中用于测量白天嗜睡的测试程序的重要补充。
