Morad Y, Lemberg H, Yofe N, Dagan Y
Department of Ophthalmology, Assaf-Harofeh Medical Center, Zerifin, Israel.
Curr Eye Res. 2000 Jul;21(1):535-42.
To determine whether parameters calculated from pupillary activity can identify subjects with sleep deprivation, and whether the objective values correlate with a subjective feeling of fatigue.
pupil size in the dark was recorded continuously for 10 minutes in 12 healthy volunteers using an infrared video camera. Two recordings were made for each subject: after a full night's sleep, and after 24 hours of sleep deprivation. Several parameters calculated from pupil size and activity were analyzed and compared with a subjective rating of the state of alertness provided by the participants in each test.
All pupillary parameters differed significantly between alertness and fatigue (p = 0.0076-0. 0186). Changes in one of the parameters - average pupillary diameter - correlated with changes in the subjective level of sleepiness (r = -0.51, p = 0.028). Although the values of most parameters differed among subjects, an absolute value of more than 25 in one parameter, cumulative pupillary variability ratio, was always associated with sleep deprivation.
On-line analysis of the pupillogram using the suggested parameters can be performed easily to produce a real-time assessment of an individual's state of alertness or fatigue that correlates with his/her subjective assessment of this state.
确定从瞳孔活动计算得出的参数是否能够识别睡眠剥夺的受试者，以及这些客观值是否与主观疲劳感相关。
使用红外摄像机对12名健康志愿者在黑暗环境中的瞳孔大小进行连续10分钟的记录。每位受试者进行两次记录：一次是在整夜睡眠后，另一次是在24小时睡眠剥夺后。分析从瞳孔大小和活动计算得出的几个参数，并与每次测试中参与者提供的警觉状态主观评分进行比较。
警觉和疲劳状态下所有瞳孔参数均存在显著差异（p = 0.0076 - 0.0186）。其中一个参数——平均瞳孔直径的变化与主观困倦程度的变化相关（r = -0.51，p = 0.028）。尽管大多数参数的值在受试者之间存在差异，但一个参数——累积瞳孔变异性比率的绝对值超过25总是与睡眠剥夺相关。
使用建议的参数对瞳孔图进行在线分析可以轻松实现，以实时评估个体的警觉或疲劳状态，且该评估与个体对自身状态的主观评估相关。
