Patrick G, Straumanis J J, Struve F A, Fitz-Gerald M J, Manno J E
Psychiatry Department, Louisiana State University School of Medicine, Shreveport 71130-3932, USA.
Clin Electroencephalogr. 1997 Jan;28(1):26-31. doi: 10.1177/155005949702800105.
The use of evoked potentials to study CNS effects of marihuana (THC) have produced inconsistent findings. Our previous pilot studies suggested that auditory P300 latencies and amplitudes, auditory P50 and somatosensory P30 amplitudes and brainstem auditory evoked potential latencies were altered in THC users. Because these findings were flawed by uncontrolled psychiatric diagnostic and medication variables, we undertook a controlled investigation of screened medically and psychiatrically normal THC users and controls. When age effects were controlled, THC related alterations of brain stem and both auditory and visual P300 responses could not be seen. This report extends our analyses to other auditory, somatosensory and visual evoked potentials. With the possible exception of an elevated auditory P50 amplitude, significant evoked potential correlates to daily THC use were not seen when normals were studied and age effects controlled.
利用诱发电位来研究大麻（四氢大麻酚）对中枢神经系统的影响，所得结果并不一致。我们之前的初步研究表明，大麻使用者的听觉P300潜伏期和波幅、听觉P50以及体感P30波幅和脑干听觉诱发电位潜伏期均有改变。由于这些研究结果受到未控制的精神诊断和药物变量的影响而存在缺陷，我们对经过筛选的医学和精神状态正常的大麻使用者及对照组进行了对照研究。在控制年龄影响后，未发现与大麻相关的脑干以及听觉和视觉P300反应改变。本报告将我们的分析扩展到其他听觉、体感和视觉诱发电位。在研究正常人群并控制年龄影响后，除了听觉P50波幅升高外，未发现与每日使用大麻有显著相关性的诱发电位。
