Seawright A A, Hrdlicka J
Aust Vet J. 1977 May;53(5):230-5. doi: 10.1111/j.1751-0813.1977.tb00195.x.
Toxic Lantana camara taxa growing in Queensland all contain the triterpene acids lantadene A, reduced lantadene A and lantadene B. These when dosed as pure compounds orally to sheep were similarly toxic at 65 to 75, 42 to 80 and 200 to 300 mg/kg body weight respectively, causing jaundice, photosensitisation, kidney and liver lesions typical of natural and experimental lantana poisoning. Because of its comparative toxicity and abundance lantadene A is the most significant toxic principle in the plant. Reduced lantadene A because of its low concentration in the leaves (5% of lantadene A) and lantadene B because of its significantly lower toxicity are thus unlikely to be of much importance in the poisoning of ruminants following consumption of the plant. In addition, the structural features of both lantadene A and B molecules given to sheep by the oral route do not conform to the chemical structures previously reported to be required for liver damaging action of the verbenaceous triterpenes administered to rabbits by the intraperitoneal route.
生长在昆士兰的有毒马缨丹类植物均含有三萜酸类物质，如马缨丹烯A、还原马缨丹烯A和马缨丹烯B。当将这些物质作为纯化合物经口给绵羊投喂时，它们的毒性相似，分别在65至75毫克/千克体重、42至80毫克/千克体重和200至300毫克/千克体重时导致黄疸、光敏反应、肾脏和肝脏损伤，这些损伤是自然和实验性马缨丹中毒的典型症状。由于马缨丹烯A的相对毒性和含量较高，它是该植物中最重要的有毒成分。还原马缨丹烯A因其在叶片中的浓度较低（为马缨丹烯A的5%），而马缨丹烯B因其毒性显著较低，因此在反刍动物食用该植物后中毒过程中不太可能起重要作用。此外，经口给绵羊投喂的马缨丹烯A和B分子的结构特征，与先前报道的经腹腔给兔子投喂马鞭草科三萜类化合物时肝脏损伤作用所需的化学结构不符。
