接种疫苗作为预防马缨丹中毒的一种可能手段。

Vaccination as a possible means of preventing lantana poisoning.

作者信息

Stewart C, Lamberton J A, Fairclough R J, Pass M A

机构信息

Department of Physiology and Pharmacology, University of Queensland, St Lucia.

出版信息

Aust Vet J. 1988 Nov;65(11):349-52. doi: 10.1111/j.1751-0813.1988.tb14262.x.

DOI:10.1111/j.1751-0813.1988.tb14262.x

PMID:3214369

Abstract

The toxic triterpene acids lantadene A and lantadene B were isolated from Lantana camara and conjugated to bovine serum albumen or haemocyanin. The conjugates were emulsified with complete Freund's adjuvant and injected into sheep and cattle. Vaccinated animals produced antibodies against the toxic compounds. Cholestasis was less severe in vaccinated than in non-vaccinated sheep challenged with a toxic dose of lantana. The results indicated a mild protective effect of vaccination against the hepatotoxic effects of lantana toxins.

摘要

从马缨丹中分离出有毒三萜酸马缨丹烯A和马缨丹烯B，并将它们与牛血清白蛋白或血蓝蛋白结合。将结合物用完全弗氏佐剂乳化后注射到绵羊和牛体内。接种疫苗的动物产生了针对这些有毒化合物的抗体。与用有毒剂量马缨丹攻击的未接种疫苗的绵羊相比，接种疫苗的绵羊胆汁淤积症状较轻。结果表明接种疫苗对马缨丹毒素的肝毒性有一定的保护作用。