卵泡期促黄体生成素水平升高在多囊卵巢综合征女性体外受精治疗中的意义
The significance of high follicular-phase luteinizing hormone levels in the treatment of women with polycystic ovarian syndrome by in vitro fertilization.
作者信息
Tarlatzis B C, Grimbizis G
机构信息
1st Department of Obstetrics & Gynecology, Aristotle University, Thessaloniki, Greece.
出版信息
J Assist Reprod Genet. 1997 Jan;14(1):1-4. doi: 10.1007/BF02765740.
Abstract
It seems, therefore, that in PCOS patients stimulated for IVF with HMG, follicular-phase LH levels have an adverse effect on follicle and oocyte numbers as well as on oocyte quality. Moreover, an inappropriately raised LH appears to have a deleterious effect on the pregnancy outcome by being associated with a greater possibility for miscarriage. On the other hand, the administration of GnRH-a in the long desensitization protocol seems to reverse the detrimental effect of increased LH concentrations on follicular and oocyte development, whereas the beneficial effect on oocyte maturity, although significant, appears to be less profound. Furthermore, GnRH-a administration is associated with a decreased risk for early abortion.
摘要
因此，在接受HMG刺激进行体外受精的多囊卵巢综合征（PCOS）患者中，卵泡期促黄体生成素（LH）水平似乎对卵泡数量、卵母细胞数量以及卵母细胞质量具有不利影响。此外，LH水平异常升高似乎对妊娠结局具有有害影响，因为其与流产可能性增加相关。另一方面，在长方案降调节中使用促性腺激素释放激素激动剂（GnRH-a）似乎可逆转LH浓度升高对卵泡和卵母细胞发育的有害影响，而对卵母细胞成熟的有益影响虽然显著，但似乎不太明显。此外，使用GnRH-a可降低早期流产风险。
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