Bitton A, Peppercorn M A, Hanrahan J P, Upton M P
Center for Inflammatory Bowel Disease, Beth Israel Hospital, Boston, Massachusetts, USA.
Am J Gastroenterol. 1996 May;91(5):1039-40.
Lung toxicity associated with 5-aminosalicylate (5-ASA) agents is a rare entity. We report the case of a 32-yr-old woman with ulcerative colitis who developed progressive shortness of breath while taking one of the 5-ASA drugs, oral mesalamine. Bilateral pulmonary infiltrates, peripheral eosinophilia, and histological findings consistent with acute pneumonitis characterized the lung injury. Although the differential diagnosis is broad, mesalamine-induced lung damage must be considered in patients who develop unexplained respiratory symptoms while taking this agent.
与5-氨基水杨酸（5-ASA）制剂相关的肺部毒性是一种罕见情况。我们报告一例32岁患有溃疡性结肠炎的女性病例，该患者在服用一种5-ASA药物——口服美沙拉嗪时出现进行性呼吸急促。双侧肺部浸润、外周血嗜酸性粒细胞增多以及符合急性肺炎的组织学表现是该肺损伤的特征。尽管鉴别诊断范围广泛，但对于在服用该药物时出现无法解释的呼吸道症状的患者，必须考虑美沙拉嗪引起的肺损伤。
