Patel M N, Kleinfeld A M, Richeiri G V, Ruben S, Hiatt M, Hegyi T
Department of Pediatrics, UMDNJ-Robert Wood Johnson Medical School, St. Peter's Medical Center, New Brunswick 08903, USA.
J Am Coll Nutr. 1997 Feb;16(1):81-4. doi: 10.1080/07315724.1997.10718653.
Free fatty acids (FFA) play essential roles in maintaining physiologic homeostasis in the newborn infant. Most of the FFA in serum is carried in complex with albumin, but a small fraction remains unbound in the aqueous phase.
This study's goal is to report the values of serum levels of unbound free fatty acids (FFAu) in pregnant women and their newborn infants at term gestation.
The measurements were made possible by the availability of the fluorescent probe for unbound FFA, acrylodated intestinal fatty acid binding protein (ADIFAB). Twenty-two mother-infant pairs were enrolled in the study. Maternal levels were obtained immediately before delivery, cord levels at the time of delivery, and infant levels after 24 hours of age.
The level of FFAu measured in maternal samples was 11.8 +/- 4 nM, in cord samples 9.2 +/- 4 nM, and in infants 13.9 +/- 3 nM. These population averages are considerably greater than those observed in healthy adults (7.5 +/- 2.5 nM). No correlation was found between cord levels and birthweight, gestational age, labor duration, mode of deliver, and infant or maternal temperature.
This investigation is the first to measure FFAu in a group of mothers and their infants and provides the technique for future investigations of the biologic activity of free fatty acids.
游离脂肪酸（FFA）在维持新生儿生理稳态中发挥着重要作用。血清中的大多数FFA与白蛋白结合存在，但有一小部分仍以游离状态存在于水相中。
本研究旨在报告足月妊娠孕妇及其新生儿血清中未结合游离脂肪酸（FFAu）的水平。
利用未结合FFA的荧光探针——丙烯酰化肠脂肪酸结合蛋白（ADIFAB）进行测量。本研究纳入了22对母婴。分别在分娩前即刻获取母亲样本水平、分娩时获取脐带样本水平以及婴儿出生24小时后获取婴儿样本水平。
母亲样本中测得的FFAu水平为11.8±4 nM，脐带样本中为9.2±4 nM，婴儿样本中为13.9±3 nM。这些总体平均值显著高于健康成年人（7.5±2.5 nM）。未发现脐带水平与出生体重、胎龄、产程、分娩方式以及婴儿或母亲体温之间存在相关性。
本研究首次对一组母亲及其婴儿的FFAu进行了测量，并为未来游离脂肪酸生物活性的研究提供了技术手段。
