Jaroszeski M J, Gilbert R, Perrott R, Heller R
Department of Chemical Engineering, University of South Florida, Tampa 33612, USA.
Melanoma Res. 1996 Dec;6(6):427-33. doi: 10.1097/00008390-199612000-00004.
Electrochemotherapy has been demonstrated to be an effective treatment for cutaneous cancers. The treatment includes administering a chemotherapeutic agent followed by electric pulses which are applied directly to the tumour. The pulses facilitate delivery of drug through the plasma membrane. Enhanced delivery is restricted to the area that has been electrically treated. Currently, electrochemotherapy is administered as a single treatment. Complete response rates are high; however, partial responses are obtained in a fraction of the treated tumours. An issue associated with this is whether or not multiple treatments would result in an improved therapy for these partially responding tumours. A multiple treatment electrochemotherapy study was implemented in order to address this issue. The study utilized subcutaneously induced murine B16 melanoma tumours in C57B1/6 mice. Results showed large tumour volume reductions in multiple treatment groups. In addition, a twofold increase in tumour doubling time and greater percentages of complete responses were found as a result of multiple treatment. These results will be utilized to augment existing clinical trials with respect to retreating tumours that have partially responded to a single electrochemotherapy treatment.
电化学疗法已被证明是治疗皮肤癌的一种有效方法。该治疗方法包括先给予一种化疗药物，然后将电脉冲直接施加于肿瘤上。这些脉冲有助于药物通过质膜递送。增强的递送仅限于接受电治疗的区域。目前，电化学疗法作为单一治疗方法进行。完全缓解率很高；然而，在一部分接受治疗的肿瘤中会出现部分缓解。与此相关的一个问题是多次治疗是否会改善这些部分缓解肿瘤的治疗效果。为了解决这个问题，开展了一项多次治疗电化学疗法研究。该研究利用皮下诱导的C57B1/6小鼠B16黑色素瘤肿瘤。结果显示多次治疗组的肿瘤体积大幅减小。此外，多次治疗使肿瘤倍增时间增加了两倍，并提高了完全缓解的百分比。这些结果将用于扩大现有临床试验，以对单次电化学疗法治疗后部分缓解的肿瘤进行再次治疗。
