Rho、Rac和Cdc42 GTP酶调节肌动蛋白细胞骨架的组织。

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton.

作者信息

Tapon N, Hall A

机构信息

Cancer Research Campaign Oncogene and Signal Transduction Group, Medical Research Council, Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.

出版信息

Curr Opin Cell Biol. 1997 Feb;9(1):86-92. doi: 10.1016/s0955-0674(97)80156-1.

DOI:10.1016/s0955-0674(97)80156-1

PMID:9013670

Abstract

Rho, Rac and Cdc42 are three Ras-related GTP-binding proteins that control the assembly and disassembly of the actin cytoskeleton in response to extracellular signals. During the past year, numerous candidate downstream targets for these GTPases have been identified using affinity chromatography and yeast two-hybrid techniques. These techniques have revealed that Rho regulates the myosin light chain phosphatase and that Rho and Rac control the synthesis of phosphatidylinositol 4,5-bisphosphate, two activities that might help to explain the effects of these GTPases on the actin cytoskeleton.

摘要

Rho、Rac和Cdc42是三种与Ras相关的GTP结合蛋白，它们响应细胞外信号控制肌动蛋白细胞骨架的组装和拆卸。在过去的一年里，使用亲和色谱法和酵母双杂交技术已经鉴定出这些GTP酶的众多候选下游靶点。这些技术表明，Rho调节肌球蛋白轻链磷酸酶，并且Rho和Rac控制磷脂酰肌醇4,5-二磷酸的合成，这两种活性可能有助于解释这些GTP酶对肌动蛋白细胞骨架的影响。