Yamada K M, Geiger B
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental Research, National Institutes of Health, Building 30, Room 421, 30 Convent Drive, MSC 4370, Bethesda MD 20892-4370, USA.
Curr Opin Cell Biol. 1997 Feb;9(1):76-85. doi: 10.1016/s0955-0674(97)80155-x.
Cell adhesions consist of multimolecular protein complexes of transmembrane adhesion receptors anchoring intracellular cytoskeletal structural proteins and signal transduction molecules. Recent advances reveal that components of cell adhesion complexes display multiple interactions and functions, which cooperate to mediate both cell adhesion and signaling. Cell-matrix and cell-cell adhesions can serve as both recipients and generators of signaling information, using hierarchical and synergistic molecular interactions regulated by aggregation, conformational changes, phosphorylation, and tension.
细胞黏附由跨膜黏附受体的多分子蛋白复合物组成，这些复合物锚定细胞内细胞骨架结构蛋白和信号转导分子。最近的研究进展表明，细胞黏附复合物的组分呈现多种相互作用和功能，它们共同协作介导细胞黏附和信号传导。细胞-基质黏附和细胞-细胞黏附既可以作为信号信息的接受者，也可以作为信号信息的产生者，利用由聚集、构象变化、磷酸化和张力调节的分级和协同分子相互作用。
