Gocke C D, Dabbs D J, Benko F A, Silverman J F
Department of Pathology, Penn State University College of Medicine, Hershey, PA, USA.
Hum Pathol. 1997 Jan;28(1):80-3. doi: 10.1016/s0046-8177(97)90283-5.
Giant cell neoplasms of the pancreas are rare tumors of uncertain histogenesis. Mutation of the KRAS oncogene is common in typical pancreatic duct adenocarcinoma. We have analyzed DNA from five pancreatic tumors with giant cells for mutations in the KRAS oncogene and found alterations of the second position of codon 12 in each case (four G > A transitions and one G > C transversion). The common mutation pattern in tumors with giant cells and duct adenocarcinoma suggests a common route to malignant transformation and may indicate a shared histogenesis. We also tested 11 cases of malignant fibrous histiocytoma, a histological mimic of pleomorphic giant cell tumor, for mutations in the KRAS oncogene. The absence of KAS mutations in each of the malignant fibrous histiocytomas (MFHs) and in other histologically similar tumors may provide assistance in the differential diagnosis of pleomorphic pancreatic tumors.
胰腺巨细胞瘤是一种组织发生不明的罕见肿瘤。KRAS癌基因的突变在典型的胰腺导管腺癌中很常见。我们分析了5例含巨细胞的胰腺肿瘤的DNA，以检测KRAS癌基因的突变，结果发现每例肿瘤密码子12的第二位均发生了改变（4例为G>A转换，1例为G>C颠换）。含巨细胞的肿瘤与导管腺癌中常见的突变模式提示了一条共同的恶性转化途径，可能表明它们有共同的组织发生。我们还检测了11例恶性纤维组织细胞瘤（一种组织学上类似多形性巨细胞瘤的肿瘤）的KRAS癌基因突变情况。每例恶性纤维组织细胞瘤及其他组织学上相似的肿瘤均未检测到KRAS突变，这可能有助于多形性胰腺肿瘤的鉴别诊断。
