大鼠中通过椎旁交感干投射至腰椎小关节的降钙素基因相关肽免疫反应性神经纤维。
CGRP-immunoreactive nerve fibers projecting to lumbar facet joints through the paravertebral sympathetic trunk in rats.
作者信息
Suseki K, Takahashi Y, Takahashi K, Chiba T, Tanaka K, Moriya H
机构信息
Department of Orthopaedic Surgery, School of Medicine, Chiba University, Japan.
出版信息
Neurosci Lett. 1996 Dec 27;221(1):41-4. doi: 10.1016/s0304-3940(96)13282-1.
We previously reported that the L5-6 facet joint is innervated from DRGs from L1 to L5 and the paravertebral sympathetic ganglia from T12 to L6 in rats. In the present study, to determine the sensory pathway from L5-6 facet joint, we placed the fluorescent carbocyanine dye, DiI, in the L5-6 facet joint, and examined the paravertebral sympathetic trunks and ganglia bilaterally. We found some DiI-labeled nerve fibers exhibiting calcitonin gene-related peptide (CGRP)-immunoreactivity, and some DiI-labeled neurons surrounded by CGRP-immunoreactive varicose fibers in the ganglia. The results suggest that a sensory pathway from the L5-6 facet joint to L1 and/or L2 DRGs is present in the paravertebral sympathetic trunk, and that sensory nerve fibers may connect with sympathetic postganglionic neurons projecting to lumbar facet joints.
我们之前报道过，大鼠的L5 - 6小关节由L1至L5的背根神经节（DRG）以及T12至L6的椎旁交感神经节支配。在本研究中，为了确定来自L5 - 6小关节的感觉通路，我们将荧光羰花青染料DiI注入L5 - 6小关节，并双侧检查椎旁交感干和神经节。我们发现一些DiI标记的神经纤维呈现降钙素基因相关肽（CGRP）免疫反应性，并且在神经节中有一些被CGRP免疫反应性曲张纤维包围的DiI标记神经元。结果表明，在椎旁交感干中存在从L5 - 6小关节到L1和/或L2背根神经节的感觉通路，并且感觉神经纤维可能与投射到腰椎小关节的交感神经节后神经元相连。
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