Martin J, Prystowsky M B, Angeletti R H
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6079.
J Neurosci Res. 1987;18(1):82-7. doi: 10.1002/jnr.490180114.
The presence of preproenkephalin mRNA in tumor cell lines derived from myeloid and mast cells was analyzed by RNA dot blot hybridization. A B-cell lymphoma was negative for preproenkephalin mRNA, but several T-cell lymphomas were positive. A mastocytoma and two macrophage cell lines were found to have high levels of preproenkephalin mRNA. Purified natural macrophages and mast cells also possessed easily detectable levels of this mRNA.
通过RNA斑点印迹杂交分析了源自髓细胞和肥大细胞的肿瘤细胞系中前脑啡肽原mRNA的存在情况。一种B细胞淋巴瘤前脑啡肽原mRNA呈阴性，但几种T细胞淋巴瘤呈阳性。发现一种肥大细胞瘤和两种巨噬细胞系有高水平的前脑啡肽原mRNA。纯化的天然巨噬细胞和肥大细胞也有易于检测到的该mRNA水平。
