Fujikane M, Katayama S, Hirata K, Yokota N
Department of Neurology, Dokkyo University School of Medicine.
Nihon Rinsho. 1997 Jan;55(1):153-7.
Actigraphy measures physiological activity by using an acceleration sensor and RAM equipped with a data logger. Since actigraphy can continuously and easily record data over a long period of time without disturbing the normal activities of subjects, it is possible to analyze a large number of subjects. Actigraphy was performed in patients with Parkinson's disease who did not exhibit trembling. Results showed that the daily motor activity of patients was lower than that of the healthy individual. Daily motor activity was also found to be correlated with Hoehn-Yahr's classification. Furthermore, side-effects due to L-dopa, such as abnormal involuntary movement and on-off phenomenon, could be objective assessed. The results of long-term actigraphic examination, conducted after anti-Parkinsonian treatment, showed that akinesia improved with time. From these findings, it is concluded that actigraphy could quantitatively assess the degree of akinesia in Parkinsonian patients. Furthermore, actigraphy may be applied to the clinical assessment of drugs.
活动记录仪通过使用加速度传感器和配备数据记录器的随机存取存储器来测量生理活动。由于活动记录仪可以在不干扰受试者正常活动的情况下长时间连续且轻松地记录数据，因此有可能对大量受试者进行分析。对未出现震颤的帕金森病患者进行了活动记录仪检查。结果显示，患者的日常运动活动低于健康个体。还发现日常运动活动与霍恩-雅尔分级相关。此外，左旋多巴引起的副作用，如异常不自主运动和开关现象，可以进行客观评估。抗帕金森病治疗后进行的长期活动记录仪检查结果显示，运动不能随时间改善。从这些发现可以得出结论，活动记录仪可以定量评估帕金森病患者的运动不能程度。此外，活动记录仪可应用于药物的临床评估。
