Roland Kaitlyn P, M D Cornett Kayla, Theou Olga, Jakobi Jennifer M, Jones Gareth R
Interdisciplinary Graduate Studies, Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada V1V 1V7.
J Aging Res. 2012;2012:468156. doi: 10.1155/2012/468156. Epub 2012 Aug 7.
Females with Parkinson's disease (PD) are vulnerable to frailty. PD eventually leads to decreased physical activity, an indicator of frailty. We speculate PD results in frailty through reduced physical activity. Objective. Determine the contribution of physical activity on frailty in PD (n = 15, 65 ± 9 years) and non-PD (n = 15, 73 ± 14 years) females. Methods. Frailty phenotype (nonfrail/prefrail/frail) was categorized and 8 hours of physical activity was measured using accelerometer, global positioning system, and self-report. Two-way ANCOVA (age as covariate) was used to compare physical activity between disease and frailty phenotypes. Spearman correlation assessed relationships, and linear regression determined associations with frailty. Results. Nonfrail recorded more physical activity (intensity, counts, self-report) compared with frail. Self-reported physical activity was greater in PD than non-PD. In non-PD, step counts, light physical activity time, sedentary time, and self-reported physical activity were related to frailty (R = 0.91). In PD, only carbidopa-levodopa dose was related to frailty (r = 0.61). Conclusion. Physical activity influences frailty in females without PD. In PD females, disease management may be a better indicator of frailty than physical activity. Further investigation into how PD associated factors contribute to frailty is warranted.
患有帕金森病（PD）的女性易患虚弱症。PD最终会导致身体活动减少，这是虚弱的一个指标。我们推测PD通过减少身体活动导致虚弱。目的：确定身体活动对PD女性（n = 15，65±9岁）和非PD女性（n = 15，73±14岁）虚弱的影响。方法：对虚弱表型（非虚弱/前期虚弱/虚弱）进行分类，使用加速度计、全球定位系统和自我报告测量8小时的身体活动。采用双向协方差分析（以年龄作为协变量）比较疾病和虚弱表型之间的身体活动情况。使用Spearman相关性评估关系，并通过线性回归确定与虚弱的关联。结果：与虚弱者相比，非虚弱者记录的身体活动更多（强度、计数、自我报告）。PD患者自我报告的身体活动比非PD患者更多。在非PD患者中，步数、轻度身体活动时间、久坐时间和自我报告的身体活动与虚弱有关（R = 0.91）。在PD患者中，只有卡比多巴-左旋多巴剂量与虚弱有关（r = 0.61）。结论：身体活动会影响非PD女性的虚弱情况。在PD女性中，疾病管理可能比身体活动更能作为虚弱的指标。有必要进一步研究PD相关因素如何导致虚弱。
