Mochio S, Oka H, Katayama K, Sato H
Department of Neurology, Jikei University School of Medicine.
Nihon Rinsho. 1997 Jan;55(1):158-62.
In Parkinson's disease, resting tremor is often the initial symptom. This report focuses on the mechanism underlying tremor in Parkinson's disease and quantitative assessment of tremor. Central factors including Vim (nucleus ventralis intermedius) in the thalamus, and peripheral factors, such as acceleration of input pathways from muscle spindles via muscle tonus, are important aspects of the tremor mechanism in Parkinson's disease. It has also been suggested that tremor in Parkinson's disease is associated with parasympathetic and sympathetic dysfunctions. Objective assessments of tremor, such as the application of surface electromyography, are useful in the diagnosis and treatment of Parkinson's disease. Actigraph, as introduced herein, is a three dimensional motor sensing apparatus. Therefore, motor counts over 0.01 G can be detected by actigraphy. To date, this device has been used for evaluating akinesia in Parkinson's disease and insomnia. In this study, actigraphy was used in Parkinson patients with tremor, and it reflected motor activity in the wrist and was associated with the severity of hand tremor. Activities of daily living (ADL) are disturbed by hyperkinesia of the hand for Parkinson patients with hand tremor. We demonstrated that actigraphy is a simple and quantitative method of assessing motor activity in Parkinson patients with tremor.
在帕金森病中，静止性震颤往往是初始症状。本报告聚焦于帕金森病震颤的潜在机制及震颤的定量评估。中枢因素，包括丘脑腹中间核（Vim），以及外周因素，如通过肌张力从肌梭传入通路的加速，是帕金森病震颤机制的重要方面。也有人提出帕金森病的震颤与副交感神经和交感神经功能障碍有关。震颤的客观评估，如表面肌电图的应用，在帕金森病的诊断和治疗中很有用。本文介绍的活动记录仪是一种三维运动传感装置。因此，通过活动记录仪可以检测到超过0.01G的运动计数。迄今为止，该设备已用于评估帕金森病的运动不能和失眠。在本研究中，活动记录仪用于患有震颤的帕金森病患者，它反映了手腕的运动活动，并与手部震颤的严重程度相关。对于患有手部震颤的帕金森病患者，日常生活活动（ADL）会受到手部运动过多的干扰。我们证明活动记录仪是评估患有震颤的帕金森病患者运动活动的一种简单且定量的方法。
