Tanaka M, Kondo S, Okamoto K, Hirai S
Department of Neurology, Gunma University School of Medicine.
Nihon Rinsho. 1997 Jan;55(1):218-21.
In many previous studies, positron emission tomography (PET) has been used to evaluate cerebral perfusion and oxygen metabolism in Parkinson's disease. In this article, these previous reports are reviewed together with our recent findings. Hypoperfusion and hypometabolism in parkinsonian brains reported previously seemed to be derived chiefly from psychiatric manifestations, including intellectual decline and depression. In our study on 34 patients with asymmetric symptoms, the blood flow and oxygen metabolism were significantly higher in the caudate head and putamen, contralateral to the predominant patient's symptoms, than in the opposite nuclei. The asymmetry in the perfusion and metabolism is clearer in the early stage of the disease or in patients without DOPA therapy. These findings suggest that the striatal dysfunction is caused by uninhibited activities, supersensitivities, or compensatory hyperactivities of the striatum.
在许多先前的研究中，正电子发射断层扫描（PET）已被用于评估帕金森病中的脑灌注和氧代谢。在本文中，将对这些先前的报告以及我们最近的发现进行综述。先前报道的帕金森病大脑中的灌注不足和代谢减退似乎主要源于精神症状，包括智力下降和抑郁。在我们对34例症状不对称患者的研究中，与主要症状对侧的尾状核头部和壳核相比，血流和氧代谢显著更高。灌注和代谢的不对称在疾病早期或未接受多巴治疗的患者中更为明显。这些发现表明，纹状体功能障碍是由纹状体的无抑制活动、超敏反应或代偿性多动引起的。
