Koller D Y, Götz M, Wojnarowski C, Eichler I
Division of Allergy and Pulmonology, University Children's Hospital, Vienna, Austria.
Arch Dis Child. 1996 Dec;75(6):498-501. doi: 10.1136/adc.75.6.498.
To evaluate the clinical use of measuring neutrophil, lymphocyte, and eosinophil activities, serum myeloperoxidase (MPO), soluble interleukin-2 receptors (sIL-2R), and eosinophil cationic protein (ECP) were measured in 98 patients with cystic fibrosis and in 85 healthy children. Serum concentrations of MPO, sIL-2R, and ECP were increased in patients with cystic fibrosis (median 807 micrograms/l, 4452 pg/ml, 48.8 micrograms/l, respectively) compared with the controls (median 319 micrograms/l, 2743 pg/ml, 9.4 micrograms/l). ECP concentrations, but not serum MPO or sIL-2R, were significantly related to disease severity assessed by the Shwachman-Kulczycki score and by pulmonary function (forced expiratory volume in one second % predicted). Neither ECP nor sIL-2R was influenced by Pseudomonas aeruginosa infection, acute pulmonary exacerbation, or atopy. Serum MPO, however, was strongly correlated with acute pulmonary exacerbation. In the light of these findings the measurement of serum ECP might thus be used for clinical monitoring and for assessing disease severity in cystic fibrosis. The measurement of serum MPO and sIL-2R did not correlate with the disease severity.
为评估测量中性粒细胞、淋巴细胞和嗜酸性粒细胞活性的临床应用价值，对98例囊性纤维化患者和85名健康儿童进行了血清髓过氧化物酶（MPO）、可溶性白细胞介素-2受体（sIL-2R）和嗜酸性粒细胞阳离子蛋白（ECP）检测。与对照组（中位数分别为319μg/l、2743pg/ml、9.4μg/l）相比，囊性纤维化患者的血清MPO、sIL-2R和ECP浓度升高（中位数分别为807μg/l、4452pg/ml、48.8μg/l）。ECP浓度与通过Shwachman-Kulczycki评分和肺功能（一秒用力呼气容积占预计值百分比）评估的疾病严重程度显著相关，而血清MPO或sIL-2R则不然。ECP和sIL-2R均不受铜绿假单胞菌感染、急性肺部加重或特应性影响。然而，血清MPO与急性肺部加重密切相关。鉴于这些发现，血清ECP的检测可用于囊性纤维化的临床监测和疾病严重程度评估。血清MPO和sIL-2R的检测与疾病严重程度无关。
