Kampov-Polevoy A, Garbutt J C, Janowsky D
Department of Psychiatry, University of North Carolina at Chapel Hill, USA.
Am J Psychiatry. 1997 Feb;154(2):269-70. doi: 10.1176/ajp.154.2.269.
The purpose of this study was to test in humans the finding from animal studies indicating an association between preference for more concentrated sweet solutions and excessive alcohol drinking.
The hedonic response to five different concentrations of sucrose solution was evaluated in 20 detoxified alcoholic and 37 nonalcoholic Caucasian men. All subjects repetitively tasted solutions with 0.05, 0.10, 0.21, 0.42, and 0.83 M sucrose concentrations and rated themselves on two scales measuring the intensity of sweetness and the likability of the solutions.
A bimodal distribution of responses to the sweet solutions occurred in the nonalcoholic comparison group, with peaks at 0.05 M and 0.42 M. In the alcoholic group, 65% of the subjects preferred the highest sucrose concentration (0.83 M), compared with only 16% of the nonalcoholic group.
The results of this exploratory study support the hypothesis suggesting a positive association between the preference for stronger sweet solutions and alcohol dependence.
本研究旨在对人体进行测试，以验证动物研究中的一项发现，即对更高浓度甜味溶液的偏好与过度饮酒之间存在关联。
对20名已戒酒的男性酒精依赖者和37名非酒精依赖的白种男性，评估其对五种不同浓度蔗糖溶液的享乐反应。所有受试者重复品尝浓度分别为0.05、0.10、0.21、0.42和0.83M的蔗糖溶液，并通过两个量表对甜度强度和溶液喜爱程度进行自我评分。
在非酒精依赖的对照组中，对甜味溶液的反应呈双峰分布，峰值出现在0.05M和0.42M处。在酒精依赖组中，65%的受试者偏好最高蔗糖浓度（0.83M），而非酒精依赖组中这一比例仅为16%。
这项探索性研究的结果支持了如下假设，即对更强甜味溶液的偏好与酒精依赖之间存在正相关。
