Agostini C, Semenzato G
Department of Clinical and Experimental Immunology, Padua University School of Medicine, Padova, Italy.
Clin Chest Med. 1996 Dec;17(4):633-45. doi: 10.1016/s0272-5231(05)70337-3.
This article covers a selected group of topics dealing with the contribution of lung immunocompetent cells in the host defense mechanisms against HIV. These include recent findings suggesting that bidirectional signals between alveolar macrophages and pulmonary cytotoxic T lymphocytes define regulatory networks, which contribute to the accumulation of HIV-specific effector cells in the lung microenvironment. The authors also emphasize the cell pattern of HIV infection in the lung, highlighting the role of the retrovirus in weakening pulmonary host defenses and its spreading into the lower respiratory tract.
本文涵盖了一组选定的主题，涉及肺免疫活性细胞在宿主抵御HIV的防御机制中的作用。这些包括最近的研究发现，表明肺泡巨噬细胞和肺细胞毒性T淋巴细胞之间的双向信号定义了调节网络，这有助于HIV特异性效应细胞在肺微环境中的积累。作者还强调了HIV在肺中的感染细胞模式，突出了逆转录病毒在削弱肺宿主防御及其扩散到下呼吸道中的作用。
