Agostini C, Chilosi M, Zambello R, Trentin L, Semenzato G
Dept of Clinical Medicine, Padua University School of Medicine, Italy.
Eur Respir J. 1993 Oct;6(9):1378-401.
Immunological defence mechanisms of the lung are provided by several different types of immunocompetent cell. Among these, the most important are lymphocytes, alveolar macrophages and neutrophils. This review focuses mainly on the pattern of physiological activities of pulmonary lymphocytes in the local host defences. The article provides an overview of the events leading to the recruitment, homing and activity of lymphocytes in the lower respiratory tract. The pathways through which the pulmonary lymphoid system recognizes, destroys and contributes to removing potentially harmful inhaled antigenic materials are also briefly discussed. The final section of the article highlights the pathogenetic role envisaged for lymphoid cells in disease states, in the context of the known biology of these cells.
肺的免疫防御机制由几种不同类型的免疫活性细胞提供。其中，最重要的是淋巴细胞、肺泡巨噬细胞和中性粒细胞。本综述主要关注肺淋巴细胞在局部宿主防御中的生理活动模式。本文概述了导致淋巴细胞在下呼吸道募集、归巢和活动的一系列事件。还简要讨论了肺淋巴系统识别、破坏并有助于清除潜在有害吸入抗原物质的途径。文章的最后一部分在这些细胞已知生物学特性的背景下，强调了淋巴细胞在疾病状态中所设想的致病作用。
