Herdy G V, al Odeh C S, Cunha J de O, Amorim A M, Ono I de C
Hospital Universitário António Pedro (HUAP), Departamento de Virologia da UFRJ.
Arq Bras Cardiol. 1991 Mar;56(3):201-5.
To study etiopathogenic and follow-up aspects of patients with myocarditis.
Among 44 cases of acute myocarditis in children studied from clinical and virological point of view, it was selected 16 which were positive to coxsackie B virus. The clinical investigation included blood test to enzyme dosage, chest X-ray, electro and echocardiogram. The virological work up to coxsackie B1, B3, B4, B5 and B6 included culture neutralization test and IgM (indirect immunofluorescence).
The positive results were: B4 in 9 (57%); B5 in 4 (25%), B1 in 2 (12%) and B3 in 1 (6%). It was not used immunosuppressive treatment. The follow-up (at least one year it was: 7 patients became free of symptoms (43%); 4 (25%) turned to be chronic dilated myocardiopathy 1 (6%) died and 4 (25%) were discharged from hospital but did not return to out-patient clinic. One of patients of chronic group during 4 years of follow-up had ventricular extrasystoles, second degree heart block and now is asymptomatic.
We did not observe significative differences among the several types of coxsackie B related to clinical course.
研究心肌炎患者的病因及随访情况。
从临床和病毒学角度对44例儿童急性心肌炎患者进行研究，从中选取16例柯萨奇B病毒检测呈阳性的患者。临床检查包括血液酶学检测、胸部X线、心电图和超声心动图。对柯萨奇B1、B3、B4、B5和B6的病毒学检查包括培养中和试验和IgM（间接免疫荧光法）。
阳性结果为：B4型9例（57%）；B5型4例（25%），B1型2例（12%），B3型1例（6%）。未采用免疫抑制治疗。随访（至少一年）结果为：7例患者症状消失（43%）；4例（25%）转变为慢性扩张型心肌病，1例（6%）死亡，4例（25%）出院但未复诊。慢性组中有1例患者在4年随访期间出现室性早搏、二度房室传导阻滞，目前无症状。
我们未观察到与临床病程相关的几种柯萨奇B病毒类型之间存在显著差异。
