用于分析人类p53基因、人类次黄嘌呤磷酸核糖转移酶（hprt）基因以及转基因啮齿动物中lacI和lacZ基因的突变的数据库和软件。
Databases and software for the analysis of mutations in the human p53 gene, the human hprt gene and both the lacI and lacZ gene in transgenic rodents.
作者信息
Cariello N F, Douglas G R, Dycaico M J, Gorelick N J, Provost G S, Soussi T
机构信息
Glaxo Wellcome, Inc., Medicines Safety Evaluation, 9.2011, 5 Moore Drive, Research Triangle Park, NC 27709, USA.
出版信息
Nucleic Acids Res. 1997 Jan 1;25(1):136-7. doi: 10.1093/nar/25.1.136.
We have created databases and software applications for the analysis of DNA mutations at the humanp53gene, the humanhprtgene and both the rodent transgeniclacIandlacZlocus. The databases themselves are stand-alone dBASE files and the software for analysis of the databases runs on IBM-compatible computers. Each database has a separate software analysis program. The software created for these databases permit the filtering, ordering, report generation and display of information in the database. In addition, a significant number of routines have been developed for the analysis of single base substitutions. One method of obtaining the databases and software is via the World Wide Web (WWW). Open the following home page with a Web Browser: http://sunsite.unc.edu/dnam/mainpage.ht ml . Alternatively, the databases and programs are available via public FTP from: anonymous@sunsite.unc.edu . There is no password required to enter the system. The databases and software are found beneath the subdirectory: pub/academic/biology/dna-mutations. Two other programs are available at the site-a program for comparison of mutational spectra and a program for entry of mutational data into a relational database.
我们创建了用于分析人类p53基因、人类hprt基因以及啮齿动物转基因lacI和lacZ位点DNA突变的数据库和软件应用程序。数据库本身是独立的dBASE文件，用于分析数据库的软件在IBM兼容计算机上运行。每个数据库都有一个单独的软件分析程序。为这些数据库创建的软件允许对数据库中的信息进行筛选、排序、报告生成和显示。此外，还开发了大量用于分析单碱基替换的程序。获取数据库和软件的一种方法是通过万维网（WWW）。用网络浏览器打开以下主页：http://sunsite.unc.edu/dnam/mainpage.html 。或者，可通过公共FTP从anonymous@sunsite.unc.edu获取数据库和程序。进入系统无需密码。数据库和软件位于子目录：pub/academic/biology/dna-mutations下。该网站还有另外两个程序——一个用于比较突变谱的程序和一个用于将突变数据输入关系数据库的程序。
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