用于分析人类p53基因突变的数据库和软件。
Database and software for the analysis of mutations at the human p53 gene.
作者信息
Cariello N F, Beroud C, Soussi T
机构信息
Glaxo, Inc., Drug Safety Assessment, Research Triangle Park, NC 27709.
出版信息
Nucleic Acids Res. 1994 Sep;22(17):3549-50.
Abstract
A computerized database containing DNA sequence information regarding human p53 mutants has been created. The database itself is in the dBASE format and contains information on nearly 3000 mutants. In addition, an IBM PC compatible software package to analyze the information in the database has been developed. Both the database and software are freely available via the Internet.
摘要
一个包含人类p53突变体DNA序列信息的计算机化数据库已创建。该数据库本身采用dBASE格式，包含近3000个突变体的信息。此外，还开发了一个用于分析数据库中信息的IBM个人计算机兼容软件包。数据库和软件均可通过互联网免费获取。
相似文献
1
Database and software for the analysis of mutations at the human p53 gene.用于分析人类p53基因突变的数据库和软件。
Nucleic Acids Res. 1994 Sep;22(17):3549-50.
2
Database and software for the analysis of mutations at the human hprt gene.用于分析人类次黄嘌呤磷酸核糖转移酶（hprt）基因突变的数据库和软件。
Nucleic Acids Res. 1994 Sep;22(17):3547-8.
3
Database and software for the analysis of mutations in the human p53 gene.用于分析人类p53基因突变的数据库和软件。
Cancer Res. 1994 Aug 15;54(16):4454-60.
4
Database and software for the analysis of mutations at the lacZ locus in transgenic rodents.用于分析转基因啮齿动物中lacZ基因座突变的数据库和软件。
Environ Mol Mutagen. 1996;28(2):145-53. doi: 10.1002/(SICI)1098-2280(1996)28:2<145::AID-EM11>3.0.CO;2-F.
5
Database and software for the analysis of mutations at the lacI gene in both transgenic rodents and bacteria.用于分析转基因啮齿动物和细菌中lacI基因突变的数据库和软件。
Environ Mol Mutagen. 1996;28(4):397-404. doi: 10.1002/(SICI)1098-2280(1996)28:4<397::AID-EM14>3.0.CO;2-A.
6
IARC p53 mutation database: a relational database to compile and analyze p53 mutations in human tumors and cell lines. International Agency for Research on Cancer.国际癌症研究机构p53突变数据库：用于汇编和分析人类肿瘤及细胞系中p53突变的关系型数据库。国际癌症研究机构。
Hum Mutat. 1999;14(1):1-8. doi: 10.1002/(SICI)1098-1004(1999)14:1<1::AID-HUMU1>3.0.CO;2-H.
7
Database of p53 gene somatic mutations in human tumors and cell lines.人类肿瘤和细胞系中p53基因体细胞突变数据库。
Nucleic Acids Res. 1994 Sep;22(17):3551-5.
8
Databases and software for the analysis of mutations in the human p53 gene, human hprt gene and both the lacI and lacZ gene in transgenic rodents.用于分析人类p53基因、人类hprt基因以及转基因啮齿动物中lacI和lacZ基因的突变的数据库和软件。
Nucleic Acids Res. 1998 Jan 1;26(1):198-9. doi: 10.1093/nar/26.1.198.
9
The human FOXL2 mutation database.人类FOXL2突变数据库。
Hum Mutat. 2004 Sep;24(3):189-93. doi: 10.1002/humu.20079.
10
Databases and software for the analysis of mutations in the human p53 gene, the human hprt gene and the lacZ gene in transgenic rodents.用于分析转基因啮齿动物中人类p53基因、人类hprt基因和lacZ基因的突变的数据库和软件。
Nucleic Acids Res. 1996 Jan 1;24(1):119-20. doi: 10.1093/nar/24.1.119.
引用本文的文献
1
The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis.TP53 网站：TP53 突变数据库和 TP53 突变分析的综合资源中心。
Nucleic Acids Res. 2013 Jan;41(Database issue):D962-9. doi: 10.1093/nar/gks1033. Epub 2012 Nov 17.
2
IGRhCellID: integrated genomic resources of human cell lines for identification.IGRhCellID：用于识别的人类细胞系综合基因组资源。
Nucleic Acids Res. 2011 Jan;39(Database issue):D520-4. doi: 10.1093/nar/gkq1075. Epub 2010 Nov 4.
3
Databases and QSAR for cancer research.用于癌症研究的数据库与定量构效关系
Cancer Inform. 2007 Feb 15;2:99-111.
4
Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin.活性氧上调 p53 和 Puma；TRAIL 和白杨素联合治疗诱导细胞凋亡的可能机制。
Br J Pharmacol. 2009 Aug;157(7):1189-202. doi: 10.1111/j.1476-5381.2009.00245.x. Epub 2009 May 11.
5
Complete sequence of p53 gene in 20 patients with lung cancer: comparison with chemosensitivity and immunohistochemistry.20例肺癌患者p53基因的完整序列：与化疗敏感性及免疫组织化学的比较
Med Oncol. 1998 Dec;15(4):255-61. doi: 10.1007/BF02787209.
6
Databases and software for the analysis of mutations in the human p53 gene, human hprt gene and both the lacI and lacZ gene in transgenic rodents.用于分析人类p53基因、人类hprt基因以及转基因啮齿动物中lacI和lacZ基因的突变的数据库和软件。
Nucleic Acids Res. 1998 Jan 1;26(1):198-9. doi: 10.1093/nar/26.1.198.
7
Databases and software for the analysis of mutations in the human p53 gene, the human hprt gene and both the lacI and lacZ gene in transgenic rodents.用于分析人类p53基因、人类次黄嘌呤磷酸核糖转移酶（hprt）基因以及转基因啮齿动物中lacI和lacZ基因的突变的数据库和软件。
Nucleic Acids Res. 1997 Jan 1;25(1):136-7. doi: 10.1093/nar/25.1.136.
8
Dominant-negative p53 mutations selected in yeast hit cancer hot spots.在酵母中筛选出的显性负性p53突变命中癌症热点区域。
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4091-5. doi: 10.1073/pnas.93.9.4091.
9
Databases and software for the analysis of mutations in the human p53 gene, the human hprt gene and the lacZ gene in transgenic rodents.用于分析转基因啮齿动物中人类p53基因、人类hprt基因和lacZ基因的突变的数据库和软件。
Nucleic Acids Res. 1996 Jan 1;24(1):119-20. doi: 10.1093/nar/24.1.119.
10
A microdissection approach to detect molecular markers during progression of prostate cancer.一种在前列腺癌进展过程中检测分子标志物的显微切割方法。
Br J Cancer. 1995 Oct;72(4):946-51. doi: 10.1038/bjc.1995.439.
本文引用的文献
1
Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.非黑素瘤皮肤癌p53基因中由阳光导致的突变热点。
Proc Natl Acad Sci U S A. 1993 May 1;90(9):4216-20. doi: 10.1073/pnas.90.9.4216.
2
Structural aspects of the p53 protein in relation to gene evolution.与基因进化相关的p53蛋白的结构方面
Oncogene. 1990 Jul;5(7):945-52.
3
A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.阳光在皮肤癌中的作用：紫外线诱导的鳞状细胞癌中的p53突变。
Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10124-8. doi: 10.1073/pnas.88.22.10124.
4
p53 mutations in human cancers.人类癌症中的p53基因突变。
Science. 1991 Jul 5;253(5015):49-53. doi: 10.1126/science.1905840.
5
Mutational hotspot in the p53 gene in human hepatocellular carcinomas.人类肝细胞癌中p53基因的突变热点
Nature. 1991 Apr 4;350(6317):427-8. doi: 10.1038/350427a0.
6
p53 mutation in hepatocellular carcinoma after aflatoxin exposure.黄曲霉毒素暴露后肝细胞癌中的p53突变
Lancet. 1991 Nov 30;338(8779):1356-9. doi: 10.1016/0140-6736(91)92236-u.
7
Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa.非洲南部肝细胞癌中p53基因的选择性G到T突变
Nature. 1991 Apr 4;350(6317):429-31. doi: 10.1038/350429a0.
8
TP53 tumor suppressor gene: a model for investigating human mutagenesis.
Genes Chromosomes Cancer. 1992 Jan;4(1):1-15. doi: 10.1002/gcc.2870040102.
Zotero 插件