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1
The alpha/beta fold family of proteins database and the cholinesterase gene server ESTHER.蛋白质数据库的α/β折叠家族和胆碱酯酶基因服务器ESTHER。
Nucleic Acids Res. 1997 Jan 1;25(1):143-6. doi: 10.1093/nar/25.1.143.
2
A cholinesterase genes server (ESTHER): a database of cholinesterase-related sequences for multiple alignments, phylogenetic relationships, mutations and structural data retrieval.胆碱酯酶基因服务器（ESTHER）：一个用于多序列比对、系统发育关系、突变和结构数据检索的胆碱酯酶相关序列数据库。
Nucleic Acids Res. 1996 Jan 1;24(1):132-6. doi: 10.1093/nar/24.1.132.
3
aCHEdb: the database system for ESTHER, the alpha/beta fold family of proteins and the Cholinesterase gene server.aCHEdb：用于ESTHER、α/β折叠蛋白家族和胆碱酯酶基因服务器的数据库系统。
Nucleic Acids Res. 1998 Jan 1;26(1):226-8. doi: 10.1093/nar/26.1.226.
4
Kinetic parameters of cholinesterase interactions with organophosphates: retrieval and comparison tools available through ESTHER database: ESTerases, alpha/beta Hydrolase Enzymes and Relatives.胆碱酯酶与有机磷酸酯相互作用的动力学参数：可通过ESTHER数据库获取的检索和比较工具：酯酶、α/β水解酶及其相关酶类。
Chem Biol Interact. 1999 May 14;119-120:567-76. doi: 10.1016/s0009-2797(99)00071-x.
5
New friendly tools for users of ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins.面向埃丝特（ESTHER）用户的新型友好工具，埃丝特是α/β-水解酶折叠超家族蛋白质的数据库。
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6
ESTHER, the database of the α/β-hydrolase fold superfamily of proteins: tools to explore diversity of functions.ESTHER 数据库：收录了 α/β-水解酶折叠超家族的蛋白质：探索功能多样性的工具。
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7
Proteins with an alpha/beta hydrolase fold: Relationships between subfamilies in an ever-growing superfamily.具有 α/β 水解酶折叠结构的蛋白质：在不断增长的超家族中各亚家族之间的关系。
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Molecular cloning and characterization of a human carboxylesterase gene.人类羧酸酯酶基因的分子克隆与特性分析
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The ESTHER database on alpha/beta hydrolase fold proteins - An overview of recent developments.ESTHER 数据库中关于 α/β 水解酶折叠蛋白的概述——近期发展情况。
Chem Biol Interact. 2023 Sep 25;383:110671. doi: 10.1016/j.cbi.2023.110671. Epub 2023 Aug 13.
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Cholinesterase-like domains in enzymes and structural proteins: functional and evolutionary relationships and identification of a catalytically essential aspartic acid.酶和结构蛋白中的类胆碱酯酶结构域：功能与进化关系以及催化必需天冬氨酸的鉴定
Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6647-51. doi: 10.1073/pnas.88.15.6647.

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ESTHER, the database of the α/β-hydrolase fold superfamily of proteins: tools to explore diversity of functions.ESTHER 数据库：收录了 α/β-水解酶折叠超家族的蛋白质：探索功能多样性的工具。
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Purification and characterization of organic solvent and detergent tolerant lipase from thermotolerant Bacillus sp. RN2.耐热芽孢杆菌 RN2 中有机溶剂和去污剂耐受脂肪酶的纯化和性质研究。
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7
Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family.神经连接素转运缺陷源于α/β-水解酶折叠蛋白家族的突变。
J Biol Chem. 2010 Sep 10;285(37):28674-82. doi: 10.1074/jbc.M110.139519. Epub 2010 Jul 8.
8
Acetylcholinesterase: from 3D structure to function.乙酰胆碱酯酶：从 3D 结构到功能。
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本文引用的文献

1
Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target.乙酰胆碱酯酶-束丝菌素复合物的晶体结构：蛇毒三指毒素与其靶标的相互作用
Structure. 1995 Dec 15;3(12):1355-66. doi: 10.1016/s0969-2126(01)00273-8.
2
A cholinesterase genes server (ESTHER): a database of cholinesterase-related sequences for multiple alignments, phylogenetic relationships, mutations and structural data retrieval.胆碱酯酶基因服务器（ESTHER）：一个用于多序列比对、系统发育关系、突变和结构数据检索的胆碱酯酶相关序列数据库。
Nucleic Acids Res. 1996 Jan 1;24(1):132-6. doi: 10.1093/nar/24.1.132.
3
Acetylcholinesterase inhibition by fasciculin: crystal structure of the complex.束丝菌素对乙酰胆碱酯酶的抑制作用：复合物的晶体结构
Cell. 1995 Nov 3;83(3):503-12. doi: 10.1016/0092-8674(95)90128-0.
4
Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.季铵配体与乙酰胆碱酯酶活性位点峡谷中的芳香族残基结合。
Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. doi: 10.1073/pnas.90.19.9031.
5
Molecular and cellular biology of cholinesterases.胆碱酯酶的分子与细胞生物学
Prog Neurobiol. 1993 Jul;41(1):31-91. doi: 10.1016/0301-0082(93)90040-y.
6
Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase.酪氨酸337在石杉碱甲与人乙酰胆碱酯酶活性位点结合中的作用。
Mol Pharmacol. 1994 Mar;45(3):555-60.
7
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.CLUSTAL W：通过序列加权、位置特异性空位罚分和权重矩阵选择提高渐进多序列比对的灵敏度。
Nucleic Acids Res. 1994 Nov 11;22(22):4673-80. doi: 10.1093/nar/22.22.4673.
8
A cluster of at least three esterase genes in Lucilia cuprina includes malathion carboxylesterase and two other esterases implicated in resistance to organophosphates.铜绿蝇中至少三个酯酶基因组成的一个基因簇，包括马拉硫磷羧酸酯酶和另外两个与有机磷抗性相关的酯酶。
Biochem Genet. 1994 Dec;32(11-12):437-53. doi: 10.1007/BF00566064.
9
Fasciculins, anticholinesterase toxins from the venom of the green mamba Dendroaspis angusticeps.束丝毒素，是绿曼巴蛇（Dendroaspis angusticeps）毒液中的抗胆碱酯酶毒素。
J Physiol (Paris). 1984;79(4):232-40.
10
Cholinesterases within neurofibrillary tangles related to age and Alzheimer's disease.与年龄和阿尔茨海默病相关的神经原纤维缠结中的胆碱酯酶。
Ann Neurol. 1987 Aug;22(2):223-8. doi: 10.1002/ana.410220206.

蛋白质数据库的α/β折叠家族和胆碱酯酶基因服务器ESTHER。

The alpha/beta fold family of proteins database and the cholinesterase gene server ESTHER.

作者信息

Cousin X, Hotelier T, Giles K, Lievin P, Toutant J P, Chatonnet A

机构信息

Différenciation Cellulaire et Croissance, INRA-ENSAM, 2 Place Viala, 34060 Montpellier, France.

出版信息

Nucleic Acids Res. 1997 Jan 1;25(1):143-6. doi: 10.1093/nar/25.1.143.

DOI:10.1093/nar/25.1.143
PMID:9016525
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC146416/
Abstract

ESTHER (for esterases, alpha/betahydrolase enzyme and relatives) is a database of sequences phylogenetically related to cholinesterases. These sequences define a homogeneous group of enzymes (carboxylesterases, lipases and hormone-sensitive lipases) sharing a similar structure of a central beta-sheet surrounded by alpha-helices. Among these proteins a wide range of functions can be found (hydrolases, adhesion molecules, hormone precursors). The purpose of ESTHER is to help comparison of structures and functions of members of the family. Since the last release, new features have been added to the server. A BLAST comparison tool allows sequence homology searches within the database sequences. New sections are available: kinetics and inhibitors of cholinesterases, fasciculin-acetylcholinesterase interaction and a gene structure review. The mutation analysis compilation has been improved with three-dimensional images. A mailing list has been created.

摘要

ESTHER（酯酶、α/β水解酶及相关酶类）是一个与胆碱酯酶有系统发育关系的序列数据库。这些序列定义了一组同源酶（羧酸酯酶、脂肪酶和激素敏感性脂肪酶），它们共享一个由α螺旋包围的中央β折叠的相似结构。在这些蛋白质中可以发现广泛的功能（水解酶、粘附分子、激素前体）。ESTHER的目的是帮助比较该家族成员的结构和功能。自上次发布以来，服务器添加了新功能。一个BLAST比较工具允许在数据库序列中进行序列同源性搜索。新增了一些板块：胆碱酯酶的动力学和抑制剂、束丝菌素-乙酰胆碱酯酶相互作用以及基因结构综述。突变分析汇编通过三维图像得到了改进。还创建了一个邮件列表。