Kogelnik A M, Lott M T, Brown M D, Navathe S B, Wallace D C
Department of Genetics and Molecular Medicine, Emory University School of Medicine, 1462 Clifton Road, Suite 446, Atlanta, GA 30322, USA.
Nucleic Acids Res. 1997 Jan 1;25(1):196-9. doi: 10.1093/nar/25.1.196.
We have continued to develop MITOMAP, a comprehensive database for the human mitochondrial DNA (mtDNA). MITOMAP uses the mtDNA sequence as the unifying element for bringing together information on mitochondrial genome structure and function, pathogenic mutations and their clinical characteristics, population associated variation and gene-gene interactions. As increasingly larger regions of the human genome are sequenced and characterized, the need for integrating such information will grow. Consequently, MITOMAP not only provides a valuable reference for the mitochondrial biologist, it will also provide a model for the development of comprehensive, multi-media information storage and retrieval systems for other components of the human genome. This paper is an update of the changes which have occurred to MITOMAP over the past year.
我们持续开发了人类线粒体DNA（mtDNA）的综合数据库MITOMAP。MITOMAP以mtDNA序列作为统一元素，整合了线粒体基因组结构与功能、致病突变及其临床特征、群体相关变异以及基因-基因相互作用等信息。随着人类基因组越来越大的区域被测序和表征，整合此类信息的需求将会增加。因此，MITOMAP不仅为线粒体生物学家提供了有价值的参考，还将为人类基因组其他组成部分开发全面的多媒体信息存储和检索系统提供一个模型。本文是对过去一年MITOMAP所发生变化的更新。
