Speitel L C
US Department of Transportation, Atlantic City International Airport, NJ 08405, USA.
Toxicology. 1996 Dec 31;115(1-3):167-77. doi: 10.1016/s0300-483x(96)03505-6.
The development of a survival model for post-crash aircraft cabin fires is described in this paper. Its development is based on an extensive review of the literature on the toxicity of combustion gases and on thermal hazards. This model is to be used as a predictive tool to gauge human survivability in full scale aircraft cabin fire tests. The extensive literature search was conducted for carbon monoxide (CO), carbon dioxide (CO2), hydrogen cyanide (HCN), low oxygen, hydrogen fluoride (HF), hydrogen chloride (HCl), hydrogen bromide (HBr), nitrogen dioxide (NO2), sulfur dioxide (SO2), acrolein (CH2CHCHO), and heat exposures. Those studies by various investigators of exposures to single and mixed gases on humans, primates, rats, and mice at different physical activity levels were compared. Regression equations were derived from those studies to give the best fit to the gas exposure concentration and duration data. The equation judged to best model the human escaping from an aircraft cabin was selected for each gas. This survival model uses incapacitation data to obtain a fractional effective dose (FED) for incapacitation (FED(I)) and lethality data, inclusive of post exposure deaths, to obtain a FED for lethality (FED(L)). The exposure time required for either FED(I) or FED(L) to reach unity, using a projected set of gas concentrations, represents the exposure time available to escape from the specified fire environment or to survive post exposure, respectively. The effect of CO2 in increasing the uptake of other gases was factored into the concentration term in the FED equation for all gases with the exception of CO2 and oxygen. Higher respiratory minute volumes due to CO2 exposure were found to be an important factor in predicting the time available to escape. This FED-based model can be applied to the evaluation of the toxicity of smoke in computer modeling of aircraft fire situations.
本文描述了坠机后飞机客舱火灾生存模型的开发。其开发基于对燃烧气体毒性和热危害相关文献的广泛综述。该模型将用作预测工具,以评估全尺寸飞机客舱火灾试验中的人员生存能力。针对一氧化碳(CO)、二氧化碳(CO₂)、氰化氢(HCN)、低氧、氟化氢(HF)、氯化氢(HCl)、溴化氢(HBr)、二氧化氮(NO₂)、二氧化硫(SO₂)、丙烯醛(CH₂CHCHO)和热暴露进行了广泛的文献检索。比较了不同研究者对处于不同身体活动水平的人类、灵长类动物、大鼠和小鼠进行单一气体和混合气体暴露的研究。从这些研究中推导出回归方程,以最佳拟合气体暴露浓度和持续时间数据。为每种气体选择了被认为最能模拟人类从飞机客舱逃生的方程。该生存模型使用失能数据来获得失能的分数有效剂量(FED(I)),并使用包括暴露后死亡在内的致死率数据来获得致死的FED(FED(L))。使用一组预测的气体浓度,FED(I)或FED(L)达到1所需的暴露时间分别代表从指定火灾环境逃生或暴露后生存的可用暴露时间。除CO₂和氧气外,所有气体的FED方程中的浓度项都考虑了CO₂增加其他气体吸收的影响。发现由于CO₂暴露导致的较高呼吸分钟通气量是预测逃生可用时间的一个重要因素。这种基于FED的模型可应用于飞机火灾情况计算机建模中烟雾毒性的评估。