Reeves S T, Wiedenfeld K R, Wrobleski J, Hardin C L, Pinosky M L
Department of Pediatric Dentistry, Medical University of South Carolina, USA.
ASDC J Dent Child. 1996 Mar-Apr;63(2):95-100.
The purpose of this study was to evaluate in a randomized, double-blinded fashion the sedative and behavioral responses of children undergoing pediatric dental procedures as outpatients and who had received a combination of either oral chloral hydrate 50 mg/kg, not to exceed 1 gm, with hydroxyzine 25 mg (Group 1); or oral midazolam 0.5 mg/kg with acetaminophen elixir 10 mg/kg (Group 2). The children were rated according to sleep, movement, crying and overall behavior at preselected intervals that included presedation, introduction to the operating suite, injection, and overall behavior. There were no statistical differences between the two groups in regards to age, weight, length of procedure, or sex. Group 1 was more asleep in the later time intervals (P < 0.05). Their were no statistically significant differences between the groups in relation to the overall evaluation for the procedure. In conclusion, midazolam/acetaminophen is as effective as chloral hydrate/hydroxyzine in the sedation of young children undergoing outpatient dental procedures.
本研究的目的是以随机、双盲方式评估门诊接受儿科牙科手术的儿童，这些儿童接受了以下两种药物组合之一的治疗：口服水合氯醛50mg/kg（不超过1g）加羟嗪25mg（第1组）；或口服咪达唑仑0.5mg/kg加对乙酰氨基酚酏剂10mg/kg（第2组）。在包括镇静前、进入手术室、注射以及总体行为等预先选定的时间间隔，根据睡眠、活动、哭闹和总体行为对儿童进行评分。两组在年龄、体重、手术时长或性别方面无统计学差异。第1组在较晚的时间间隔睡眠程度更高（P<0.05）。两组在手术总体评估方面无统计学显著差异。总之，咪达唑仑/对乙酰氨基酚在门诊牙科手术中对幼儿的镇静效果与水合氯醛/羟嗪一样有效。
