Verbeken E K, Cauberghs M, van de Woestijne K P
Laboratorium voor Pathologische Ontleedkunde I, Universitaire Ziekenhuizen St. Rafaël en Gasthuisberg, Leuven, Belgium.
J Appl Physiol (1985). 1996 Dec;81(6):2468-80. doi: 10.1152/jappl.1996.81.6.2468.
Three-dimensional reconstructions of the septal system of normal human lungs revealed that airways course within the interlobular septa, i.e., between the two blades formed by the peripheral boundaries of adjacent lobuli of whatever order, and enter the supplied pulmonary unit at its side. This is not in keeping with the classic view of a peripheral airway in the center of a lung unit and submitted to radial traction by attached alveolar septa. The basic design of the lung fibrous scaffold appears to be in conformity with the laws of fractal geometry. Similar reconstructions in centrilobular emphysema disclosed tortuosities of both intra-acinar and interlobular septa, with consequent distortions of the corresponding intraseptal bronchioles and collapse of lung units of different sizes. It is suggested that in centrilobular emphysema competition for space, besides intrinsic airways narrowing because of inflammation and loss of elastic recoil, is a cause of flow limitation.
对正常人类肺部间隔系统的三维重建显示，气道走行于小叶间隔内，即在由任何级别的相邻小叶的外周边界形成的两个叶间之间，并从其侧面进入所供应的肺单位。这与传统观点中肺单位中心的外周气道受到附着的肺泡间隔的径向牵拉不一致。肺纤维支架的基本设计似乎符合分形几何定律。在小叶中心型肺气肿中的类似重建显示，腺泡内和小叶间隔均有迂曲，相应的间隔内细支气管随之扭曲，不同大小的肺单位塌陷。有人提出，在小叶中心型肺气肿中，除了由于炎症和弹性回缩丧失导致的气道固有狭窄外，空间竞争也是导致气流受限的一个原因。
