Scott M L, Voak D, Jones J W, Avent N D, Liu W, Hughes-Jones N, Sonneborn H
IBGRL, Bristol, UK.
Transfus Clin Biol. 1996;3(6):391-6. doi: 10.1016/s1246-7820(96)80051-6.
Both cDNA RHD sequences and reactivity with monoclonal anti-D have been reported in a number of partial D phenotypes, where parts (some epitopes) of the normal D antigen are missing, and anti-D of restricted specificity may be made in response to challenge with normal D positive blood. This paper analyses these reports together and proposes a model for the structure which comprise the epitopes of the Rh D antigen. Some epitopes are proposed to be comprised of continuous peptide sequence within one extracellular loop, whereas others require interactions between two or the extracellular peptide loops.
在一些部分D表型中，已报道了cDNA RHD序列以及与抗-D单克隆抗体的反应性，其中正常D抗原的部分（一些表位）缺失，并且针对正常D阳性血液的刺激可能会产生特异性受限的抗-D。本文综合分析了这些报道，并提出了一个包含Rh D抗原表位的结构模型。一些表位被认为由一个细胞外环内的连续肽序列组成，而其他表位则需要两个或更多细胞外肽环之间的相互作用。
