Tippett P
Medical Research Council Blood Group Unit, University College, London, U.K.
J Immunogenet. 1990 Aug-Oct;17(4-5):247-57. doi: 10.1111/j.1744-313x.1990.tb00878.x.
Forty-six numbered Rh antigens which are detected in serological tests are extant; antigens which were most recently numbered are of high or of low incidence. The identification of high incidence Rh antigens through studies involving cells with rare Rh phenotypes, including Rhnull cells, is described briefly. The serological investigations and family studies required to show that a low incidence antigen is an Rh antigen are illustrated by a description of the JAL (Rh48) antigen. Heterogeneity of polymorphic Rh antigens revealed by using monoclonal antibodies (MABS) is demonstrated by consideration of the Rh antigen D. A summary of results of serological tests shows that monoclonal anti-D antibodies define eight D epitopes. Partial D antigens of the D categories are reassessed in terms of expression of D epitopes.
目前已发现46种在血清学检测中可检测到的编号Rh抗原；最近编号的抗原发生率有高有低。简要描述了通过涉及具有罕见Rh表型的细胞（包括Rhnull细胞）的研究来鉴定高发生率Rh抗原的方法。通过对JAL（Rh48）抗原的描述，说明了证明低发生率抗原是Rh抗原所需的血清学研究和家系研究。通过对Rh抗原D的分析，展示了使用单克隆抗体（MABs）揭示的多态性Rh抗原的异质性。血清学检测结果总结表明，单克隆抗-D抗体定义了8个D表位。根据D表位的表达情况，对D类别中的部分D抗原进行了重新评估。
