Estil S, Haaskjold E, Bjerknes R, Refsum S B
Department of Ophthalmology, National Hospital, Oslo, Norway.
Acta Ophthalmol Scand. 1995 Dec;73(6):496-500. doi: 10.1111/j.1600-0420.1995.tb00323.x.
The early cell kinetic response in the rat corneal and conjunctival epithelia was studied after a single topical application of dipivefrine, adrenaline and timolol with and without benzalkonium chloride. Benzalkonium chloride alone in different concentrations, 0.004%, 0.01%, 0.02% and 0.04%, respectively, was also evaluated. The stathmokinetic method and the tritiated thymidine technique were used to estimate the mitotic rate and the labelling index. Dipivefrine (Propine) gave a significant depression of the mitotic rate almost to the same extent as adrenaline in the corneal epithelium, whereas no changes were found in the limbal area and in the conjunctiva. Timolol (Oftan) with or without benzalkonium chloride, and benzalkonium chloride in different concentrations gave no obvious changes of the mitotic rate. No distinct drug effects on the labelling index were observed.
在大鼠角膜和结膜上皮单次局部应用双匹夫林、肾上腺素和噻吗洛尔（有无苯扎氯铵）后，研究了其早期细胞动力学反应。还分别评估了不同浓度（0.004%、0.01%、0.02%和0.04%）的单独苯扎氯铵。采用静止期细胞分析法和氚标记胸腺嘧啶核苷技术来估计有丝分裂率和标记指数。双匹夫林（Propine）使角膜上皮的有丝分裂率显著降低，几乎与肾上腺素降低的程度相同，而在角膜缘区域和结膜中未发现变化。含或不含苯扎氯铵的噻吗洛尔（Oftan）以及不同浓度的苯扎氯铵均未使有丝分裂率发生明显变化。未观察到对标记指数有明显的药物作用。
