Haaskjold E, Refsum S B, Bjerknes R, Paulsen T O
Institute of Pathology, University of Oslo, Norway.
Cell Tissue Kinet. 1988 Nov;21(6):389-94. doi: 10.1111/j.1365-2184.1988.tb00798.x.
Many cell kinetic studies are based on the assumption that tritiated thymidine injected into an animal is available for incorporation into DNA for only a short time, and that it labels all cells in the S phase. The present study indicates that this is not the fact for the rat corneal epithelium. The labelling index (LI) declines considerably from the limbal area to the central cornea, while the mitotic rate is almost constant all over the corneal epithelium. The LI should therefore not be used as the only criterion in the assessment of proliferation rate.
注入动物体内的氚标记胸腺嘧啶核苷仅在短时间内可用于掺入DNA，并且它标记S期的所有细胞。本研究表明，对于大鼠角膜上皮而言并非如此。标记指数（LI）从角膜缘区域到角膜中央显著下降，而整个角膜上皮的有丝分裂率几乎恒定。因此，LI不应作为评估增殖率的唯一标准。
