Khomenko A G, Chukanov V I, Korneev A A
Central NII of Tuberculosis RAMN, Moscow.
Probl Tuberk. 1996(6):42-4.
M. tuberculosis examined in 717 patients with pulmonary tuberculosis appeared resistant to chemotherapy in 67.2% of cases. Whereas chronic patients developed drug resistance (DR) as secondary DR in 90.2% of cases, new cases with DR (50.1% of the examinees) seemed to be infected with drug-resistant M. tuberculosis. 2-stage chemotherapy with 4-5 drugs terminates bacterial discharge within first 3 months of treatment in the majority of the patients, especially if early correction of chemotherapy is used by the results of early determination M. tuberculosis drug sensitivity.
在717例肺结核患者中检测的结核分枝杆菌，67.2%的病例显示对化疗耐药。慢性患者发生的耐药（DR）90.2%为继发性耐药，而新发耐药病例（占受检者的50.1%）似乎感染了耐药结核分枝杆菌。多数患者采用4 - 5种药物的两阶段化疗在治疗的前3个月内可终止排菌，特别是如果根据早期测定的结核分枝杆菌药敏结果对化疗进行早期调整的话。
