Krücken J, Schmitt-Wrede H P, Markmann-Mulisch U, Wunderlich F
Division of Molecular Parasitology and Biological-Medical Research Centre, Heinrich-Heine-University, Duesseldorf, Germany.
Biochem Biophys Res Commun. 1997 Jan 3;230(1):167-70. doi: 10.1006/bbrc.1996.5876.
We report the identification of a novel mouse cDNA encoding IAP38, a putative plasma membrane protein of 38 kDa in splenic macrophages, B cells and T cells. The expression of iap38 is induced by blood-stage infections of Plasmodium chabaudi malaria and is testosterone-sensitive in non-immune mice. However, when mice have acquired testosterone-resistant immunity to P. chabaudi, there is an about 40-fold increase in the expression of iap38, which has then largely lost its responsiveness to infection and testosterone. The gene iap38 is suggested to be involved in imparting spleen cells the ability to mediate testosterone-resistant immunity to P. chabaudi malaria.
我们报告了一种新型小鼠cDNA的鉴定，该cDNA编码IAP38，一种在脾巨噬细胞、B细胞和T细胞中推定的38 kDa质膜蛋白。iap38的表达由查巴迪疟原虫血液期感染诱导，且在非免疫小鼠中对睾酮敏感。然而，当小鼠获得对查巴迪疟原虫的睾酮抗性免疫时，iap38的表达增加约40倍，此时其对感染和睾酮的反应性已大幅丧失。iap38基因被认为参与赋予脾细胞介导对查巴迪疟原虫疟疾的睾酮抗性免疫的能力。
