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使用同种异体骨对感染性髋关节置换术进行再植入。

Reimplantation of infected hip arthroplasties using bone allografts.

作者信息

Wang J W, Chen C E

机构信息

Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Taiwan, Republic of China.

出版信息

Clin Orthop Relat Res. 1997 Feb(335):202-10.

PMID:9020219
Abstract

Twenty-two patients with deep infection of an hip prosthesis received delayed reimplantation using bone allografts. Sixteen were done using noncemented components and 6 using femoral components that were fixed with antibiotic impregnated cement. Bulk allografts were used at the acetabular site in 2 patients and at the femoral site in 4 patients. Morselized allografts were used at the acetabular site in 20 patients and at the femoral site in 10 patients. The causative organisms were virulent in 10 hips and low virulent in 12 hips. At an average followup of 4 years (range, 2-7 years), 91% of patients were free of infection and 73% had a successful functional result. Two had a recurrent infection; 1 of them had a pseudomonas infection and another had a methicillin resistant Staphylococcal infection. The recurrence of infection tended to be higher if the causative organism was virulent. The use of bone allografts at the staged reimplantation of the infected hip arthroplasty did not increase the incidence of recurrent infection. Both cemented and noncemented reimplantations had a successful result in eradicating the infection. However, hybrid reimplantation with a cemented femoral component and fixed porous acetabular component had a better functional outcome than noncemented reimplantation using porous femoral component and nonfixed acetabular component.

摘要

22例髋关节假体深部感染患者接受了使用同种异体骨移植的延迟再植入手术。16例使用非骨水泥型假体组件,6例使用抗生素骨水泥固定的股骨组件。2例患者在髋臼部位使用大块同种异体骨移植,4例患者在股骨部位使用。20例患者在髋臼部位使用颗粒状同种异体骨移植,10例患者在股骨部位使用。10例髋关节的致病微生物毒力强,12例髋关节的致病微生物毒力弱。平均随访4年(范围2 - 7年),91%的患者无感染,73%的患者功能恢复成功。2例患者发生复发性感染;其中1例为铜绿假单胞菌感染,另1例为耐甲氧西林葡萄球菌感染。如果致病微生物毒力强,感染复发率往往更高。在感染性髋关节置换术的分期再植入中使用同种异体骨移植并未增加复发性感染的发生率。骨水泥型和非骨水泥型再植入在根除感染方面均取得了成功结果。然而,使用骨水泥固定的股骨组件和固定多孔髋臼组件的混合再植入比使用多孔股骨组件和非固定髋臼组件的非骨水泥型再植入功能结果更好。

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