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儿童意外经皮六氯酚中毒

Accidental percutaneous hexachlorophane intoxication in children.

作者信息

Goutières F, Aicardi J

出版信息

Br Med J. 1977 Sep 10;2(6088):663-5. doi: 10.1136/bmj.2.6088.663.

DOI:10.1136/bmj.2.6088.663
PMID:902044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1631881/
Abstract

Eighteen children with normal skin were accidentally intoxicated by a talc powder containing 6% hexachlorophane. Four died and two remained paraplegic. The clinical picture was intracranial hypertension, eight patients developing signs of spinal cord damage. The condition seemed to result from massive intramyelinic oedema. In the spinal cord vascular disturbances may occur as mechanical complications of oedema, giving rise to permanent sequelae.

摘要

18名皮肤正常的儿童意外中毒,中毒物质为一种含有6%六氯酚的滑石粉。4名儿童死亡,2名儿童仍截瘫。临床表现为颅内高压,8名患者出现脊髓损伤体征。这种情况似乎是由大量髓鞘内水肿导致的。在脊髓中,血管紊乱可能作为水肿的机械并发症出现,从而导致永久性后遗症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3934/1631881/2f4011b18f0f/brmedj00480-0022-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3934/1631881/212f85e42b35/brmedj00480-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3934/1631881/2f4011b18f0f/brmedj00480-0022-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3934/1631881/212f85e42b35/brmedj00480-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3934/1631881/2f4011b18f0f/brmedj00480-0022-b.jpg

相似文献

1
Accidental percutaneous hexachlorophane intoxication in children.儿童意外经皮六氯酚中毒
Br Med J. 1977 Sep 10;2(6088):663-5. doi: 10.1136/bmj.2.6088.663.
2
Hexachlorophane challenged.受到六氯酚的挑战。
Br Med J. 1972 Mar 18;1(5802):705.
3
Absorption of hexachlorophane from dusting powder on newborn infant's skin.六氯酚从新生儿皮肤扑粉中的吸收情况。
J Hyg (Lond). 1974 Oct;73(2):311-5. doi: 10.1017/s0022172400024177.
4
[Caustic diaper dermatitis and encephalitis secondary to the application of talcum contaminated with hexachlorophene].因使用被六氯酚污染的滑石粉导致的苛性尿布皮炎和脑炎
Ann Dermatol Venereol. 1984;111(9):789-97.
5
Outbreak of accidental hexachlorophene poisoning in France.
Lancet. 1982 Jan 9;1(8263):91-5. doi: 10.1016/s0140-6736(82)90225-2.
6
Absorption of hexachlorophane from infants' skin.
Lancet. 1972 Aug 19;2(7773):384-5. doi: 10.1016/s0140-6736(72)91780-1.
7
Proceedings: Absorption of hexachlorophane from newborn infants' skin.论文集:新生婴儿皮肤对六氯酚的吸收
J Clin Pathol. 1974 Nov;27(11):931. doi: 10.1136/jcp.27.11.931-d.
8
[Caustic diaper dermatitis and toxic encephalopathy following the application of talc contaminated by hexachlorophene].[使用被六氯酚污染的滑石粉后发生的腐蚀性尿布皮炎和中毒性脑病]
Ann Pediatr (Paris). 1986 Sep;33(7):587-92.
9
The absorption of hexachlorophane from Ultralanum ointment.从优乐散药膏中六氯酚的吸收情况
Br J Dermatol. 1975 Aug;93(2):209-13. doi: 10.1111/j.1365-2133.1975.tb06743.x.
10
Hexachlorophene poisoning.六氯酚中毒
Lancet. 1982 Feb 27;1(8270):500. doi: 10.1016/s0140-6736(82)91464-7.

引用本文的文献

1
Comparison of hexachlorophane and chlorhexidine powders in prevention of neonatal infection.六氯酚与洗必泰粉末预防新生儿感染的比较。
Arch Dis Child. 1980 Apr;55(4):277-80. doi: 10.1136/adc.55.4.277.

本文引用的文献

1
Hexachlorophene effects on the rat brain: study of high doses by light and electron microscopy.六氯酚对大鼠脑的影响:高剂量的光镜和电镜研究
Arch Environ Health. 1971 Aug;23(2):114-8. doi: 10.1080/00039896.1971.10665966.
2
Acute hexachlorophene encephalopathy: clinico-neuropathological correlation.
Acta Neuropathol. 1974;28(2):93-103. doi: 10.1007/BF00710320.
3
Hexachlorophene encephalopathy.
Acta Neuropathol. 1973;23(4):326-33. doi: 10.1007/BF00687462.
4
Hexachlorophene myelinopathy in premature infants.
J Pediatr. 1973 Jun;82(6):976-81. doi: 10.1016/s0022-3476(73)80428-7.
5
Cutaneous absorption of hexachlorophene in low-birth-weight infants.
J Pediatr. 1973 Jun;82(6):972-5. doi: 10.1016/s0022-3476(73)80427-5.
6
Hexachlorophene toxicity. Human experience at the Armed Forces Institute of Pathology.六氯酚中毒。美国武装部队病理研究所的人体研究经验。
Pediatrics. 1973 Feb;51(2):395-9.
7
Blood levels of hexachlorophene in neonates.新生儿体内六氯酚的血液水平。
Aust Paediatr J. 1972 Oct;8(5):246-9. doi: 10.1111/j.1440-1754.1972.tb01832.x.
8
How toxic is hexachlorophene?六氯酚的毒性如何?
Pediatrics. 1972 Aug;50(2):229-35.
9
Neurotoxicity of hexachlorophene in the human: I. A clinicopathologic study of 248 children.
Pediatrics. 1974 Dec;54(6):689-95.
10
Absorption of hexachlorophane from infants' skin.
Lancet. 1972 Aug 19;2(7773):384-5. doi: 10.1016/s0140-6736(72)91780-1.