儿童意外经皮六氯酚中毒
Accidental percutaneous hexachlorophane intoxication in children.
作者信息
Goutières F, Aicardi J
出版信息
Br Med J. 1977 Sep 10;2(6088):663-5. doi: 10.1136/bmj.2.6088.663.
Abstract
Eighteen children with normal skin were accidentally intoxicated by a talc powder containing 6% hexachlorophane. Four died and two remained paraplegic. The clinical picture was intracranial hypertension, eight patients developing signs of spinal cord damage. The condition seemed to result from massive intramyelinic oedema. In the spinal cord vascular disturbances may occur as mechanical complications of oedema, giving rise to permanent sequelae.
摘要
18名皮肤正常的儿童意外中毒，中毒物质为一种含有6%六氯酚的滑石粉。4名儿童死亡，2名儿童仍截瘫。临床表现为颅内高压，8名患者出现脊髓损伤体征。这种情况似乎是由大量髓鞘内水肿导致的。在脊髓中，血管紊乱可能作为水肿的机械并发症出现，从而导致永久性后遗症。
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本文引用的文献
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Hexachlorophene effects on the rat brain: study of high doses by light and electron microscopy.六氯酚对大鼠脑的影响：高剂量的光镜和电镜研究
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Blood levels of hexachlorophene in neonates.新生儿体内六氯酚的血液水平。
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How toxic is hexachlorophene?六氯酚的毒性如何？
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Neurotoxicity of hexachlorophene in the human: I. A clinicopathologic study of 248 children.
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Absorption of hexachlorophane from infants' skin.
Lancet. 1972 Aug 19;2(7773):384-5. doi: 10.1016/s0140-6736(72)91780-1.
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