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IGF2 is parentally imprinted in human preimplantation embryos.

作者信息

Lighten A D, Hardy K, Winston R M, Moore G E

出版信息

Nat Genet. 1997 Feb;15(2):122-3. doi: 10.1038/ng0297-122.

DOI:10.1038/ng0297-122
PMID:9020833
Abstract
摘要

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IGF2 is parentally imprinted in human preimplantation embryos.胰岛素样生长因子2(IGF2)在人类植入前胚胎中呈亲本印记表达。
Nat Genet. 1997 Feb;15(2):122-3. doi: 10.1038/ng0297-122.
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Expression of mRNA for the insulin-like growth factors and their receptors in human preimplantation embryos.胰岛素样生长因子及其受体的mRNA在人类植入前胚胎中的表达。
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Parental genomic imprinting of the human IGF2 gene.人类胰岛素样生长因子2(IGF2)基因的亲本基因组印记
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Hypomethylation of the P3 promoter is associated with up-regulation of IGF2 expression in human osteosarcoma.P3启动子的低甲基化与人类骨肉瘤中IGF2表达的上调相关。
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An enhancer element at the Igf2/H19 locus drives gene expression in both imprinted and non-imprinted tissues.Igf2/H19基因座处的增强子元件在印记组织和非印记组织中均驱动基因表达。
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