一个人类候选精子发生基因RBM1，在有袋类动物的Y染色体上保守且扩增。
A human candidate spermatogenesis gene, RBM1, is conserved and amplified on the marsupial Y chromosome.
作者信息
Delbridge M L, Harry J L, Toder R, O'Neill R J, Ma K, Chandley A C, Graves J A
机构信息
School of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia.
出版信息
Nat Genet. 1997 Feb;15(2):131-6. doi: 10.1038/ng0297-131.
Three genes, RBM1, DAZ and TSPY, map to a small region of the long arm of the human Y chromosome which is deleted in azoospermic men. RBM1, but not DAZ or TSPY, has a Y-linked homologue in marsupials which is transcribed in the testis. This suggests that RBM1 has been retained on the Y chromosome because of a critical male-specific function. Marsupial RBM1 is closely related to human RBM1, but, like the related autosomal gene hnRNPG, lacks the amplification of an exon. This suggests that RBM1 evolved from hnRNPG at least 130 million years ago and has undergone internal amplification in primates, as well as independent amplification in several therian [corrected] lineages.
三个基因，即RBM1、DAZ和TSPY，定位于人类Y染色体长臂的一个小区域，该区域在无精子症男性中缺失。RBM1在有袋类动物中有一个Y连锁同源物，在睾丸中表达，而DAZ和TSPY则没有。这表明RBM1由于关键的雄性特异性功能而保留在Y染色体上。有袋类动物的RBM1与人类RBM1密切相关，但与相关的常染色体基因hnRNPG一样，缺乏一个外显子的扩增。这表明RBM1至少在1.3亿年前从hnRNPG进化而来，在灵长类动物中经历了内部扩增，以及在几个兽类谱系中独立扩增。
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