一种海鱼——鲽（Pleuronectes platessa）谷胱甘肽S-转移酶基因簇的结构与表达
Structure and expression of a cluster of glutathione S-transferase genes from a marine fish, the plaice (Pleuronectes platessa).
作者信息
Leaver M J, Wright J, George S G
机构信息
NERC Unit of Aquatic Biochemistry, University of Stirling, Scotland, U.K.
出版信息
Biochem J. 1997 Jan 15;321 ( Pt 2)(Pt 2):405-12. doi: 10.1042/bj3210405.
Abstract
Glutathione S-transferases are involved in the detoxification of reactive electrophilic compounds, including intracellular metabolites, drugs, pollutants and pesticides. A cluster of three glutathione S-transferase genes, designated GSTA, GSTA1 and GSTA2, was isolated from the marine flatfish, plaice (Pleuronectes platessa). GSTA and GSTA1 code for protein products with 76% amino acid identity. GSTA2 appears to contain a single nucleotide deletion which would render any product non-functional. All of these genes consist of six exons of similar sizes and greater than 70% nucleotide identity, and are interrupted by five introns of differing sizes. GSTA and GSTA1 mRNAs were present in a range of tissues, while GSTA2 mRNA was no detected. Expression of GSTA mRNA was increased in plaice intestine and spleen by pretreatment with beta-naphthoflavone, and expression of both GSTA and GSTA1 mRNAs was increased in plaice liver and gill by pretreatment with the peroxisome proliferating agent perfluoro-octanoic acid.
摘要
谷胱甘肽S-转移酶参与活性亲电化合物的解毒过程，这些化合物包括细胞内代谢物、药物、污染物和杀虫剂。从海产比目鱼鲽（Pleuronectes platessa）中分离出一组三个谷胱甘肽S-转移酶基因，命名为GSTA、GSTA1和GSTA2。GSTA和GSTA1编码的蛋白质产物具有76%的氨基酸同一性。GSTA2似乎包含一个单核苷酸缺失，这会使任何产物失去功能。所有这些基因均由六个大小相似且核苷酸同一性大于70%的外显子组成，并被五个大小不同的内含子隔开。GSTA和GSTA1的mRNA存在于多种组织中，而未检测到GSTA2的mRNA。用β-萘黄酮预处理后，鲽肠道和脾脏中GSTA mRNA的表达增加；用过氧化物酶体增殖剂全氟辛酸预处理后，鲽肝脏和鳃中GSTA和GSTA1 mRNA的表达均增加。
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