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1
Peroxisome proliferator activated receptors: transcriptional regulators of adipogenesis, lipid metabolism and more...过氧化物酶体增殖物激活受体：脂肪生成、脂质代谢及其他方面的转录调节因子
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2
The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.谷胱甘肽S-转移酶超基因家族：谷胱甘肽S-转移酶的调控及其同工酶在癌症化学保护和耐药性中的作用。
Crit Rev Biochem Mol Biol. 1995;30(6):445-600. doi: 10.3109/10409239509083491.
3
Purification and characterization of a recombinant human Theta-class glutathione transferase (GSTT2-2).重组人θ类谷胱甘肽转移酶（GSTT2-2）的纯化与鉴定
Biochem J. 1996 May 1;315 ( Pt 3)(Pt 3):727-32. doi: 10.1042/bj3150727.
4
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation.一种前列腺素J2代谢物结合过氧化物酶体增殖物激活受体γ并促进脂肪细胞分化。
Cell. 1995 Dec 1;83(5):813-9. doi: 10.1016/0092-8674(95)90194-9.
5
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.15-脱氧-Δ12,14-前列腺素J2是脂肪细胞决定因子PPARγ的一种配体。
Cell. 1995 Dec 1;83(5):803-12. doi: 10.1016/0092-8674(95)90193-0.
6
Cloning and characterization of the major hepatic glutathione S-transferase from a marine teleost flatfish, the plaice (Pleuronectes platessa), with structural similarities to plant, insect and mammalian Theta class isoenzymes.海洋硬骨鱼比目鱼（鲽鱼，Pleuronectes platessa）主要肝脏谷胱甘肽S-转移酶的克隆与特性分析，该酶与植物、昆虫及哺乳动物θ类同工酶具有结构相似性。
Biochem J. 1993 May 15;292 ( Pt 1)(Pt 1):189-95. doi: 10.1042/bj2920189.
7
Characterization of an ethylene-responsive glutathione S-transferase gene cluster in carnation.香石竹中一个乙烯响应型谷胱甘肽S-转移酶基因簇的特性分析
Plant Mol Biol. 1993 Apr;22(1):43-58. doi: 10.1007/BF00038994.
8
Chemical and molecular regulation of enzymes that detoxify carcinogens.对致癌物进行解毒的酶的化学和分子调控。
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2965-9. doi: 10.1073/pnas.90.7.2965.
9
Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.脂肪酸和类视黄醇通过激活过氧化物酶体增殖物激活受体-视黄醇X受体异二聚体来控制脂质代谢。
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2160-4. doi: 10.1073/pnas.90.6.2160.
10
A glutathione S-transferase with glutathione-peroxidase activity from Arabidopsis thaliana. Molecular cloning and functional characterization.一种来自拟南芥的具有谷胱甘肽过氧化物酶活性的谷胱甘肽S-转移酶。分子克隆与功能表征。
Eur J Biochem. 1993 Sep 1;216(2):579-86. doi: 10.1111/j.1432-1033.1993.tb18177.x.

一种海鱼——鲽（Pleuronectes platessa）谷胱甘肽S-转移酶基因簇的结构与表达

Structure and expression of a cluster of glutathione S-transferase genes from a marine fish, the plaice (Pleuronectes platessa).

作者信息

Leaver M J, Wright J, George S G

机构信息

NERC Unit of Aquatic Biochemistry, University of Stirling, Scotland, U.K.

出版信息

Biochem J. 1997 Jan 15;321 ( Pt 2)(Pt 2):405-12. doi: 10.1042/bj3210405.

DOI:10.1042/bj3210405
PMID:9020873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1218083/
Abstract

Glutathione S-transferases are involved in the detoxification of reactive electrophilic compounds, including intracellular metabolites, drugs, pollutants and pesticides. A cluster of three glutathione S-transferase genes, designated GSTA, GSTA1 and GSTA2, was isolated from the marine flatfish, plaice (Pleuronectes platessa). GSTA and GSTA1 code for protein products with 76% amino acid identity. GSTA2 appears to contain a single nucleotide deletion which would render any product non-functional. All of these genes consist of six exons of similar sizes and greater than 70% nucleotide identity, and are interrupted by five introns of differing sizes. GSTA and GSTA1 mRNAs were present in a range of tissues, while GSTA2 mRNA was no detected. Expression of GSTA mRNA was increased in plaice intestine and spleen by pretreatment with beta-naphthoflavone, and expression of both GSTA and GSTA1 mRNAs was increased in plaice liver and gill by pretreatment with the peroxisome proliferating agent perfluoro-octanoic acid.

摘要

谷胱甘肽S-转移酶参与活性亲电化合物的解毒过程，这些化合物包括细胞内代谢物、药物、污染物和杀虫剂。从海产比目鱼鲽（Pleuronectes platessa）中分离出一组三个谷胱甘肽S-转移酶基因，命名为GSTA、GSTA1和GSTA2。GSTA和GSTA1编码的蛋白质产物具有76%的氨基酸同一性。GSTA2似乎包含一个单核苷酸缺失，这会使任何产物失去功能。所有这些基因均由六个大小相似且核苷酸同一性大于70%的外显子组成，并被五个大小不同的内含子隔开。GSTA和GSTA1的mRNA存在于多种组织中，而未检测到GSTA2的mRNA。用β-萘黄酮预处理后，鲽肠道和脾脏中GSTA mRNA的表达增加；用过氧化物酶体增殖剂全氟辛酸预处理后，鲽肝脏和鳃中GSTA和GSTA1 mRNA的表达均增加。